기본 정보
- CAS
141200-24-0- 표준 SMILES
Cc1oc(-c2ccccc2)nc1CCC(=O)c1ccc(CC2SC(=O)NC2=O)cc1- InChIKey
QQKNSPHAFATFNQ-UHFFFAOYSA-N- 분자식
- C23H20N2O4S
- 평균 분자량
- 420.5 g/mol
- 단동위원소 질량
- 420.1143783
개요
Darglitazone is an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. Darglitazone may be able to abrogate acute cerebral inflammatory responses via its suppression of proinflammatory gene expression.
이름 및 식별자
- 우선 이름
- Darglitazone
- IUPAC
- 5-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl]methyl]-1,3-thiazolidine-2,4-dione
- 현지명
- 다르글리타존
- 영어명
- darglitazone
- 분자식
- C23H20N2O4S
- 분자량
- 420.48
이름 및 동의어
Darglitazone141200-24-0darglitazonaDTXSID3057644AVP9C03Z3KCP-86325CP-86325-2 FREE ACIDCP86325DTXCID40314332,4-Thiazolidinedione, 5-((4-(3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl)phenyl)methyl)-, (+-)-darglitazonumRefChem:130959
이름 더 보기
다르글리타존2,4-Thiazolidinedione, 5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-oral,UCP2,corticosterone,PPAR-γ,CP86325,Darglitazone,Diabetes,CP-86325,Inhibitor,PPAR,inhibit,Peroxisome proliferator-activated receptors,CP 86325,thiazolidinedione
CP-86,3255-(4-(3-(5-methyl-2-phenyl-4-oxazolyl)propionyl)benzyl)-2,4-thiazolidinedione5-(4-(3-(5-Methyl-2-phenyl-oxazol-4-yl)-propionyl)-benzyl)-thiazolidine-2,4-dioneDarglitazone [INN]CP 863255-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl]methyl]-1,3-thiazolidine-2,4-dione5-(4-(3-(5-methyl-2-phenyloxazol-4-yl)propanoyl)benzyl)thiazolidine-2,4-dione5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methyl)-1,3-thiazolidine-2,4-dione
데이터베이스 식별자
- CAS
141200-24-0
물성
구조 계산 물성
- XLogP
- 4.1
- 극성 표면적
- 115 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 643
물리화학적 성질
- 밀도
- 1.306 · 1.306±0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 20 · DMSO:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)DMF:20.0(Max Conc. mg/mL);47.56(Max Conc. mM)
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 6.22 · 6.22±0.50(Predicted)
- 색상
- White to light yellow
화학 및 산업
응용 분야
용도Darglitazone is a TZD (thiazolidinedione) that increases the sensiticirt od clls to insulin, stimulating insulin-induced P13K activity at submicromolar concentrations. It increases insulin effectiveness in diabetes mellitus subjects.
공급사16 곳
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