CAS 156-51-4 Phenelzine Sulfate (HCID 61100)

이름 및 식별자

우선 이름: Phenelzine Sulfate
IUPAC: 2-phenylethylhydrazine;sulfuric acid
현지명: 페넬진황산염
영어명: Phenelzine Sulfate
분자식: C8H14N2O4S
분자량: 234.27

이름 및 동의어

Phenelzine sulfate156-51-4Phenelzine sulphatePhenelzine acid sulfateHydrazine, (2-phenylethyl)-, sulfate (1:1)Phenethylhydrazine sulfate (1:1)2-Phenylethylhydrazine sulphateNSC-1709572-Phenylethylhydrazine hydrogen sulphatePhenelzine sulfate (USP)Phenelzine sulfate [USP]2681D7P965

이름 더 보기

페넬진황산염Phenelzine Sulfate (1517006)wl7p1531ep-411alazinkalganS-1544alacine

NSC170957Sulfate, PhenelzineRefChem:55843205-856-0AlazinePHENELZINE SULFATE SALTPhenethylhydrazine sulfateEstinerval

데이터베이스 식별자

CAS: 156-51-4
PubChem CID: 61100
DTXSID: DTXSID3021144
ChEMBL: CHEMBL1200895
ChEBI: CHEBI:8061
UNII: 2681D7P965
EC Number: 205-856-0

물성

구조 계산 물성

극성 표면적: 121 Å²
수소 결합 공여자 수: 4
수소 결합 수용자 수: 6
회전 가능 결합 수: 3
무거운 원자 수: 15
형식 전하: 0
복잡도: 159

물리화학적 성질

녹는점: 166.5 · 166.5-167.5 °C
저장 조건: 2 · 2-8°C
용해도: 물에 자유롭게 용해됩니다. 에탄올(96%)과 에테르에는 거의 녹지 않습니다.
물리적 상태: 고체
색상: White to off-white
생물학적 소스: synthetic
수용성: 50 mg/mL, · water: 50mg/mL, clear to slightly hazy, colorless to faintly yellow
Merck: 13 · 13,7300
주요 응용: 의약품(소분자)
InChI: InChI=1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChIKey: RXBKMJIPNDOHFR-UHFFFAOYSA-N
SMILES: C1(CCNN)C=CC=CC=1.S(=O)(=O)(O)O

화학적 성질

A white powder or pearly platelets.

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Other Safety InformationIMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Human health tier I assessment；IMAP assessments - Hydrazine, (2-phenylethyl)-, sulfate (1:1): Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 3 (100%)

독성 정보

Carcinogen Classification · 5건

Phenelzine sulfate

Group 3: Not classifiable as to its carcinogenicity to humans

Volume 24: (1980) Some Pharmaceutical Drugs；Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)

1987

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Phenelzine sulfate

vLess-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

안전 데이터

wgk: 3
rtecs: MV8750000
ridadr: UN 2811 6.1/PG 3
독성: LD50 orally in mice: 156 mg/kg (Gylys)
HS 번호: 2928002500
risk_code: 22
hazard_code: Xn
포장분류: III
위험 등급: 6.1(b)
Hazard Classifications: Acute Tox. 3 Oral
스토리지 클래스: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

화학 및 산업

약리 정보

FDA Pharmacological Classification · 2건

PHENELZINE SULFATE

Monoamine Oxidase Inhibitors [MoA]; Monoamine Oxidase Inhibitor [EPC]

MeSH Pharmacological Classification · 2건

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.

A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)

응용 분야 · 2건

용도Phenelzine Sulfate is a hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidep ressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.

일반 설명Phenelzine sulfate, 2-(phenylethyl)hydrazine sulfate(Nardil), is an effective antidepressant agent. A mechanismbasedinactivator, it irreversibly inactivates the enzyme orits cofactor, presumably after oxidation to the diazine,which can then break up into molecular nitrogen, a hydrogen atom, and a phenethyl free radical. The latter would bethe active species in irreversible inhibition.