기본 정보
- CAS
15394-62-4- 표준 SMILES
C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1- InChIKey
LCTZPQRFOZKZNK-UHFFFAOYSA-N- 분자식
- C20H24N+
- 평균 분자량
- 278.4 g/mol
- 단동위원소 질량
- 278.19087477
개요
4-(diphenylmethylene)-1,1-dimethylpiperidin-1-ium is a diarylmethane.
이름 및 식별자
- 우선 이름
- Diphemanil
- IUPAC
- 4-benzhydrylidene-1,1-dimethylpiperidin-1-ium
이름 및 동의어
DiphemanilDiphemanil ionDiphemanil cationDiphemanil [WHO-DD]15394-62-4UNII-Q26TX1UD0WQ26TX1UD0W4-(Diphenylmethylene)-1,1-dimethylpiperidiniumPiperidinium, 4-(diphenylmethylene)-1,1-dimethyl-DTXSID70469684-(diphenylmethylidene)-1,1-dimethylpiperidin-1-iumRefChem:134625
이름 더 보기
DTXCID5026968MLS002154192CAS-62-97-5NCGC00016283-01SMR001233482SPBio_002218Prestwick0_000079Prestwick1_000079
데이터베이스 식별자
- CAS
15394-62-4- PubChem CID
- 6127
- DTXSID
DTXSID7046968- ChEMBL
CHEMBL1201340- ChEBI
CHEBI:93636- UNII
- Q26TX1UD0W
- Nikkaji
- J384.059J
물성
구조 계산 물성
- XLogP
- 4.4
- 극성 표면적
- 0 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 0
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 21
- 형식 전하
- 1
- 복잡도
- 335
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
화학 및 산업
약리 정보
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
PharmacodynamicsDiphemanil Methylsulfate is a quaternary ammonium anticholinergic. It binds muscarinic acetycholine receptors and thereby decreases secretory excretion of stomach acids as well as saliva and sweat.
Mechanism of Action
Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. M3 receptors are located in the smooth muscles of the blood vessels, as well as in the lungs. This means they cause vasodilation and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands which help to stimulate secretion in salivary glands and other glands of the body.
Absorption, Distribution and ExcretionPoorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%.
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