Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Uridine 5'-triphosphate
UTP TRISODIUM SALT · URIDINE-5'-TRIPHOSPHATE TRISODIUM SALT · UTP-NA · UTP Sodium · Uridine 5'-triphosphate · Uridine 5'-(tetrahydrogen triphosphate) · pppU · 5’-utp
식별자 및 물리적 특성
| CAS No. | 63-39-8 |
|---|---|
| 분자식 | C9H15N2O15P3 |
| 평균 분자량 | 484.14 g/mol |
| 단동위원소 질량 | 483.96852767 g/mol |
| SMILES | O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1 |
| InChIKey | PGAVKCOVUIYSFO-XVFCMESISA-N |
| PubChem CID | 6133 |
| ChEMBL | CHEMBL336296 |
| ChEBI | CHEBI:15713 |
| EC No. | 200-558-7 |
| DTXSID | DTXSID0041147 |
화학 및 물리적 성질
| XLogP | -5.8 |
|---|---|
| 극성 표면적 | 259 |
| 수소 결합 공여자 수 | 7 |
| 수소 결합 수용자 수 | 15 |
| 회전 가능 결합 수 | 8 |
| 무거운 원자 수 | 29 |
| 형식 전하 | 0 |
| 복잡도 | 839 |
| 물질 분류 | Biological Agents -> Nucleic Acids and Derivatives |
| 의약품 | Pharmaceuticals -> Listed in ZINC15 |
| Physical Description | Solid |
| Collision Cross Section | 187 Ų [M+H]+ [CCS Type: DTMethod: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]178.55 Ų [M-H]- [CCS Type: DTMethod: single field calibrated with Agilent tune mix (Agilent)]188.5 Ų [M+Na]+ |
| 밀도 | 2.106±0.06 g/cm3(Predicted) |
| 인화점 | 113 °C |
| 저장 조건 | Sealed in dry,2-8°C |
| 용해도 | Easily soluble (water) |
| pKa(산도 계수) | pK1:7.58 (25°C) |
| 물리적 상태 | 액체 |
| 색상 | 무색의 |
| pH | 7.0 ± 0.1 |
| 생물학적 소스 | yeast (Candida Utilis) |
| 용해도 | Water : ≥ 150 mg/mL (309.83 mM) |
| InChIKey | PGAVKCOVUIYSFO-XVFCMESISA-N |
| SMILES | C(OP(=O)(O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O |
| EPA | Uridine 5'-(tetrahydrogen triphosphate) (63-39-8) |
안전 및 규제
| 규제 정보 | Uridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
|---|---|
| 유해성 요약 | A skin and strong eye irritantHarmful by ingestion[Ark Pharm MSDS] |
| 수질 위해 등급(WGK) | 1 |
| 위험 문구(R) | 20/21/22-68/20/21/22 |
| 위험 표시 | Xn |
| 안전 문구(S) | 22-26-36 |
| 기존화학 물질 | KE-35244 |
용도
개요
Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
용도
Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).