Uridine 5'-triphosphate
기본 정보
- CAS
63-39-8- 표준 SMILES
O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1- InChIKey
PGAVKCOVUIYSFO-XVFCMESISA-N- 분자식
- C9H15N2O15P3
- 평균 분자량
- 484.14 g/mol
- 단동위원소 질량
- 483.96852877
개요
UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a uridine 5'-phosphate and a pyrimidine ribonucleoside 5'-triphosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).
이름 및 식별자
- 우선 이름
- Uridine 5'-triphosphate
- IUPAC
- [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
- 영어명
- UTP
- 분자식
- C9H15N2O15P3
- 분자량
- 484.14
이름 및 동의어
uridine 5'-triphosphateuridine triphosphate63-39-8UteplexMagnesium UTPUTP, MagnesiumTriphosphate, UridineMg UTPMagnesium Uridine TriphosphateTriphosphate, Magnesium UridineDTXSID0041147INS-316
이름 더 보기
UTP TRISODIUM SALTURIDINE-5'-TRIPHOSPHATE TRISODIUM SALTUTP-NAUTP SodiumpppU5’-utpUTP, 3NA
UT0S826Z60[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate(((2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphateRefChem:901473DTXCID8021147(((((((2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonic acid200-558-7Uridine 5'-(tetrahydrogen triphosphate)
데이터베이스 식별자
- CAS
63-39-8- PubChem CID
- 6133
- DTXSID
물성
구조 계산 물성
- XLogP
- -5.8
- 극성 표면적
- 259 Ų
- 수소 결합 공여자 수
- 7
- 수소 결합 수용자 수
- 15
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 839
실험 및 물리화학적 성질
Chemical ClassesBiological Agents -> Nucleic Acids and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
Physical DescriptionSolid
Collision Cross Section
180.1 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
178.55 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
186.9 Ų [M+H]+
물리화학적 성질
- 밀도
- 2.106 · 2.106±0.06 g/cm3(Predicted)
- 인화점
- 113 °C · 113 °C
- 저장 조건
- 2 · Sealed in dry,2-8°C
- 용해도
- Easily soluble (water)
- 산도 계수 (pKa)
- 1 · pK1:7.58 (25°C)
- 물리적 상태
- 액체
- 색상
- 무색의
- 수소이온지수(pH)
- 7 · 7.0 ± 0.1
- 생물학적 소스
- yeast (Candida Utilis)
- 수용성
- 150 mg/mL · Water : ≥ 150 mg/mL (309.83 mM)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory InformationUridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazards SummaryA skin and strong eye irritant; Harmful by ingestion; [Ark Pharm MSDS]
안전 데이터
- wgk
- 1
- risk_code
- 20/21/22-68/20/21/22
- hazard_code
- Xn
- safety_code
- 22-26-36
- 기존화학 물질
- KE-35244
화학 및 산업
약리 정보
Cellular LocationsCytoplasm
Metabolite PathwaysAmikacin Action Pathway
용도 및 제조
Uses
Pyrimidine analog of adenosine triphosphate (ATP); Used to treat cystic fibrosis; [Merck Index]
Use (kg; approx.) in Germany (2009): >10
응용 분야
개요Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
용도Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).
상·하류 제품 정보
상류 원료
관련 반응
20건
화합물 노트
불러오는 중…