Uridine 5'-triphosphate

HCID 6133CAS 63-39-8

기본 정보

표준 SMILES: O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1
InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N
분자식: C9H15N2O15P3
평균 분자량: 484.14 g/mol
단동위원소 질량: 483.96852767

개요

UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as a mouse metabolite and an Escherichia coli metabolite. It is a uridine 5'-phosphate and a pyrimidine ribonucleoside 5'-triphosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).

이름 및 식별자

우선 이름: Uridine 5'-triphosphate
IUPAC: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
영어명: UTP
분자식: C9H15N2O15P3
분자량: 484.14

이름 및 동의어

uridine 5'-triphosphateuridine triphosphate63-39-8UteplexDTXSID0041147INS-316UT0S826Z60[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphateMagnesium UTPUTP, MagnesiumTriphosphate, UridineMg UTP

이름 더 보기

UTP TRISODIUM SALTURIDINE-5'-TRIPHOSPHATE TRISODIUM SALTUTP-NAUTP SodiumpppU5’-utpUTP, 3NA

Magnesium Uridine TriphosphateTriphosphate, Magnesium Uridine(((2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy-hydroxyphosphoryl) phosphono hydrogen phosphateRefChem:901473DTXCID8021147(((((((2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)phosphonic acid200-558-7Uridine 5'-(tetrahydrogen triphosphate)

데이터베이스 식별자

CAS: 63-39-8
PubChem CID: 6133
DTXSID: DTXSID0041147
ChEMBL: CHEMBL336296
ChEBI: CHEBI:15713
UNII: UT0S826Z60
EC Number: 200-558-7
Nikkaji: J4.827E

물성

구조 계산 물성

XLogP: -5.8
극성 표면적: 259 Å²
수소 결합 공여자 수: 7
수소 결합 수용자 수: 15
회전 가능 결합 수: 8
무거운 원자 수: 29
형식 전하: 0
복잡도: 839

실험 및 물리화학적 성질

Chemical ClassesBiological Agents -> Nucleic Acids and Derivatives

DrugsPharmaceuticals -> Listed in ZINC15

Physical DescriptionSolid

Collision Cross Section · 3건

187 Å² [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]

178.55 Å² [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]

188.5 Å² [M+Na]+

물리화학적 성질

밀도: 2.106 · 2.106±0.06 g/cm3(Predicted)
인화점: 113 °C · 113 °C
저장 조건: 2 · Sealed in dry,2-8°C
용해도: Easily soluble (water)
산도 계수 (pKa): 1 · pK1:7.58 (25°C)
물리적 상태: 액체
색상: 무색의
수소이온지수(pH): 7 · 7.0 ± 0.1
생물학적 소스: yeast (Candida Utilis)
수용성: 150 mg/mL · Water : ≥ 150 mg/mL (309.83 mM)
InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N
SMILES: C(OP(=O)(O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](O)[C@@H]1O
EPA: 5 · Uridine 5'-(tetrahydrogen triphosphate) (63-39-8)

안전 및 규제

유해성 정보

Regulatory InformationUridine triphosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryA skin and strong eye irritant; Harmful by ingestion; [Ark Pharm MSDS]

안전 데이터

wgk: 1
risk_code: 20/21/22-68/20/21/22
hazard_code: Xn
safety_code: 22-26-36
기존화학 물질: KE-35244

화학 및 산업

약리 정보

Cellular LocationsCytoplasm

Metabolite PathwaysAmikacin Action Pathway

용도 및 제조

Uses · 2건

Pyrimidine analog of adenosine triphosphate (ATP); Used to treat cystic fibrosis; [Merck Index]

Use (kg; approx.) in Germany (2009): >10

응용 분야 · 2건

개요Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

용도Uridine 5′-triphosphate trisodium salt solution has been used to increase the intracellular Ca2+ levels in rat primary tracheal epithelial cells. It has also been used as a nucleotide substrate to analyze the activity of MutT homologue 1 (MTH1).

상·하류 제품 정보

상류 원료

하류 제품

Uridine 5'-monophosphate guanosine 5'-(tetrahydrogen triphosphate)UDP UDP-ALPHA-D-N-ACETYLGALACTOSAMINE, DISODIUM SALT

공급사50 곳

北京华美互利生物化工010-56205725 · [email protected]

杭州启因生物科技有限责任公司17368759907 · [email protected]

广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]

Zhejiang Hengkang Pharmaceutical Co., Ltd.+86-576-83372028 +86-18868723926 · [email protected]

上海遐瑞医药科技有限公司+86-021-61551413 · [email protected]

추가 설명 · 1건

정의UTP is a pyrimidine ribonucleoside 5'-triphosphate having uracil as the nucleobase. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a pyrimidine ribonucleoside 5'-triphosphate and a uridine 5'-phosphate. It is a conjugate acid of an UTP(4-) and an UTP(3-).