Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
옥살산
디카르복실산 · 옥사린산,디히드레이트 · 옥살산 · 옥사린산,디히드레이트(OXALICACID,DIHYDRATE) · 수산2수화물 · ETHANEDIOIC ACID · Oxalate Acid · OXALIC ACID 2H2O
식별자 및 물리적 특성
| CAS No. | 6153-56-6 |
|---|---|
| 분자식 | C2H2O4.2H2O |
| 평균 분자량 | 126.07 g/mol |
| 단동위원소 질량 | 126.01643791 g/mol |
| SMILES | O.O.O=C(O)C(=O)O |
| InChIKey | GEVPUGOOGXGPIO-UHFFFAOYSA-N |
| PubChem CID | 61373 |
| ChEMBL | CHEMBL5315063 |
| EC No. | 612-167-2 |
| DTXSID | DTXSID2075003 |
| 현지명 | 옥살산 |
화학 및 물리적 성질
| 극성 표면적 | 76.6 |
|---|---|
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 6 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 8 |
| 형식 전하 | 0 |
| 복잡도 | 71.5 |
| 물질 분류 | Other Classes -> Organic Acids |
| 향료 | Fragrance Ingredient (Oxalic acid dihydrate) -> IFRA transparency List |
| LogP(분배 계수) | -0.81 |
| 밀도 | 1.65 g/cm³1.653 @25 °C1,65 g/cm3 |
| 용해도 | Solubility in water, g/100ml at 20 °C: 13-14H2O: 20°C에서 용해성 1M, 투명, 무색 |
| Animal Drugs | EMA approved medicines: Veterinary medicine |
| 녹는점 | 101-102 °C189.5 °C104-106 °C(lit.) |
| 증기압 | 0.54 [mm Hg] @105 °C<0.01 mm Hg ( 20 °C) |
| Physical Description | Large CrystalsDry PowderOther SolidLiquidColorless solid[ICSC] Colorless hygroscopic crystals[Sigma-Aldrich MSDS]COLOURLESS CRYSTALS. |
| 끓는 점 | 108-109°C |
| 증기 밀도 | 4.4 (vs air) |
| 인화점 | 157°C |
| 저장 조건 | Store at +5°C to +30°C. |
| 물리적 상태 | 분말/고체 |
| 비중 | 1.65 |
| 색상 | 노란색에서 노란색-녹색 |
| pH | ~1.0 (25℃, 1M in H2O) |
| 용해도 | 138g/L(20℃) |
| Merck | 14,6911 |
| BRN | 3679436 |
| 안정성 | 안정적인. 염기, 산 염화물, 강철, 은, 은 화합물, 습기와 호환되지 않습니다. 금속과의 접촉을 피하십시오. |
| InChI | 1S/C2H2O4.2H2O/c3-1(4)2(5)6/h(H,3,4)(H,5,6)2*1H2 |
| InChIKey | GEVPUGOOGXGPIO-UHFFFAOYSA-N |
| SMILES | [H]O[H].[H]O[H].OC(=O)C(O)=O |
| NIST | Oxalic acid dihydrate(6153-56-6) |
| EPA | Oxalic acid dihydrate (6153-56-6) |
| Absorption | cut-off at 303nm in H2O at 1M |
화학적 성질
Oxalic acid dihydrate occurs as colorless crystals or a white crystalline powder; it is odorless. It sublimes at 150–160 °C and effloresces in warm, dry air. One gram is soluble in 7 mL of water, 2 mL of boiling water, 2.5 mL of ethanol, 1.8 mL of boiling ethanol, 100 mL of diethyl ether, and 5.5 mL of glycerol; it is insoluble in benzene, chloroform, and petroleum ether. The pH of a 0.1 mol/L solution is 1.3. It has low toxicity; (rabbit, dermal) is 2000 mg/kg.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 1.1% (6 of 561) of reports.DangerH302+H312 (12.7%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oralacute toxicity, dermal]P260, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 561 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: Ethanedioic acid, dihydrateEthanedioic acid, dihydrate is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Ethanedioic acid, dihydrate are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Oxalic acid dihydrate: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment |
| 화재 위험 | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. |
| 유해성 요약 | Causes burnsIngestion may have effects on calcium balanceRepeated or prolonged exposure may cause kidney stones[ICSC] Causes burnsInhalation may cause corrosive injuries to upper respiratory tract and lungsHarmful by ingestion and skin absorptionMay have teratogenic effectsTargets the kidney, nerves, blood, and eyes[Sigma-Aldrich MSDS] See Oxalic acid. |
| EC 분류 | Symbol: XnR: 21/22S: (2)-24/25 |
| UN 분류 | UN Hazard Class: 8UN Pack Group: III |
| Chemical Dangers | Decomposes on contact with hot surfaces or flames. This produces formic acid and carbon monoxide. The solution in water is a medium strong acid. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with some silver compounds. This produces explosive silver oxalate. Attacks some forms of plastic. |
| Packaging and Labelling | Do not transport with food and feedstuffs. |
| Hazard Classes and Categories | Acute Tox. 4 (98.8%)Acute toxicity - category 4 |
| 소화 | Use water spray, powder, foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 응급 조치 | Fresh air, rest. Half-upright position. Refer immediately for medical attention.Remove contaminated clothes. Rinse skin with plenty of water or shower for at least 15 minutes. Refer for medical attention .Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. |
| 안전 보관 | Separated from strong oxidants and food and feedstuffs. |
| 누출 처리 | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance, protective gloves and safety goggles. Sweep spilled substance into covered plastic containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. |
| Eye Prevention | Wear face shield or eye protection in combination with breathing protection. |
| Fire Prevention | NO open flames. |
| Inhalation Risk | Evaporation at 20 °C is negligiblea harmful concentration of airborne particles can, however, be reached quickly when dispersed. |
| Skin Prevention | Protective gloves. Protective clothing. |
| Exposure Prevention | PREVENT DISPERSION OF DUST! |
| Ingestion Prevention | Do not eat, drink, or smoke during work. Wash hands before eating. |
| Inhalation Prevention | Use ventilation (not if powder), local exhaust or breathing protection. |
| Threshold Limit Values (TLV) | 1.0 [mg/m3]2.0 [mg/m3]1 mg/m |
| Treatment | Acute Exposure: If oxalic acid is swallowed, immediately give the person water or milk, unless instructed otherwise by a health care provider. DO NOT give water or milk if the person is having symptoms (such as vomiting, convulsions, or a decreased level of alertness) that make it hard to swallow. If acute exposure occurs to the eyes, irrigate opened eyes for several minutes under running water. Chronic exposure: in some patients with primary hyperoxaluria type 1, pyridoxine treatment (vitamin B6) may decrease oxalate excretion and prevent kidney stone formation. |
| 건강 영향 | Because it binds vital nutrients such as calcium, long-term consumption of foods high in oxalic acid can be problematic. Healthy individuals can safely consume such foods in moderation, but those with kidney disorders, gout, rheumatoid arthritis, or certain forms of chronic vulvar pain (vulvodynia) are typically advised to avoid foods high in oxalic acid or oxalates. The calcium oxalate precipitate (better known as kidney stones) obstruct the kidney tubules. Conversely, calcium supplements taken along with foods high in oxalic acid can cause calcium oxalate to precipitate out in the gut and drastically reduce the levels of oxalate absorbed by the body (by 97% in some cases.) Chronically high levels of oxalic acid are associated with at least 2 inborn errors of metabolism including: Type I primary hyperoxaluria and Primary hyperoxaluria. Oxalate stones in primary hyperoxaluria tend to be severe, resulting in relatively early kidney damage (before age 20), which impairs the excretion of oxalate leading to a further acceleration in accumulation of oxalate in the body. After the development of renal failure patients may develop oxalate deposits in the bones, joints and bone marrow. Severe cases may develop haematological problems such as anaemia and thrombocytopaenia. The deposition of oxalate in the body is sometimes called "oxalosis" to be distinguished from "oxaluria" which refers to oxalate in the urine. |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 노출 경로 | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. Serious local effects by all routes of exposure. |
| 독성 요약 | The affinity of divalent metal ions is sometimes reflected in their tendency to form insoluble precipitates. Thus in the body, oxalic acid also combines with metals ions such as Ca2+, Fe2+, and Mg2+ to deposit crystals of the corresponding oxalates, which irritate the gut and kidneys. (2) Therefore the toxicity of oxalic acid is due to kidney failure caused by precipitation of solid calcium oxalate, the main component of kidney stones. Oxalic acid can also cause joint pain due to the formation of similar precipitates in the joints. Ingestion of ethylene glycol results in oxalic acid as a metabolite that can also cause acute kidney failure. |
| Signs and Symptoms | Cough. Sore throat. Burning sensation. Shortness of breath. Laboured breathing. Headache.Redness. Pain. Skin burns.Redness. Pain. Blurred vision. Burns.Sore throat. Burning sensation. Abdominal pain. Laboured breathing. Convulsions. Paralysis. Cardiac dysrhythmia. Shock or collapse.Oxalic acid poisoning symptoms include weakness, burning in the mouth, death from cardiovascular collapse, on the respiratory system, throat – burning in the throat, abdominal pain, nausea, vomiting, diarrhea, convulsions, and coma. |
| Carcinogen Classification | No indication of carcinogenicity (not listed by IARC). (L135) |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | Yes |
| RTECS 번호 | RO2450000 |
| 운송 번호(UN) | UN 3261 8/PG 3 |
| 독성 | LD50 orally in Rabbit: 375 mg/kg |
| 관세 코드 | 29171100 |
| 위험 문구(R) | 21/22-41 |
| 위험 표시 | Xn,C |
| 안전 문구(S) | 24/25-39-37-36-26 |
| 포장분류 | III |
| 위험 등급 | 8Acute Tox. 4 DermalAcute Tox. 4 OralEye Dam. 1 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
Oxalic acid dihydrate is a purifying agent in pharmaceutical industry, special in antibiotic medication, such as Oxytetracycline , Chloramphenicol , etc; * Precipitating agent in Rare-earth mineral processing; * Bleaching agent in the textile activities, wood pulp bleaching; * Rust-remover for Metal treatment; * Grinding agent, such as Marble polishing; * Waste water treatment, removing calcium from water.
일반 설명
Oxalic acid dihydrate (OAD) crystals are reported to be monoclinic with P21/n space group. The electron density of OAD has been obtained using X-ray diffraction studies under high resolution.