10198-40-0[60Co]GUTLYIVDDKVIGB-OUBTZVSYSA-NCobalt Co-60 is under investigation in clinical trial NCT02891083 (Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer).
10198-40-0DTXSID80891751안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
Source: Neutron activation of stable Co-59; Half-Life: 5.3 years Effective Half-Life: 10 days Specific Activity: 1,100 Ci/g Decay Mode: Beta GI Absorption: 5-30% Lung Clearance Half-Time: >100 days for oxides, hydroxides, halides, and nitrates; 10-100 days for other compounds; Critical Organ: Total body Internal Toxicity: High Annual Limit on Intake: 0.030 mCi Tenth-Value Layer: 34.8 mm Pb Gamma Ray Constant: 13.2 R/h @ 1 cm per mCi Radiation Energy (MeV): Beta 0.313 (99.8%); Gamma 1.17 (99.8%); Gamma 1.33 (100%) Radiation Accidents: 31 accidents reported with 211 injuries and 30 deaths plus C0-60 was involved in 16 incidents of Melting of Radioactive Materials; [See Glossary for references.] See Radiation, ionizing.
Cobalt-60
Radioactive material
Atomic number: 27
Cobalt-60m
Radioactive material
Atomic number: 27
Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitus. Cobalt may also have mutagenic and carcinogenic effects. Exposure to cobalt radiation causes cell damage and can lead to severe burns and death at high doses. (L29, L30)
Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
Cobalt-59 is the naturally occurring stable form of cobalt. Of the 9 major radioactive isotopes, only Co-57 and Co-60 have half-lives longer than 80 days. Cobalt-60 is formed by neutron activation in nuclear reactors and particle accelerators. [Argonne] Co-60 is used in medicine for instrument sterilization and radiation therapy for cancer; Used in industrial radiography and irradiation of food and grain; [Waltar, Appendix A-D]
Radioactive cobalt is used for commercial and medical purposes, such as for sterilizing medical equipment and consumer products, radiation therapy for treating cancer patients, manufacturing plastics, and irradiating food. (L29)
개요코발트는 +2가와 +3가를 나타내는 전이성금속산화물로 지각(Earth crust)의 0.0025%를 차지하는 것으로 알려져 있는 지구상의 33번째로 많은 량을 차지하는 천연물질이다 (ATSDR, 2004).
용도니켈 제련의 부산물로 얻어진다. 금속코발트는 피셔법에 의한 석유합성의 촉매로서 이용하는 정도로 용도가 많지 않으나 합금으로는 대단히 중요한 용도가 있다. 주조한 그대로 사용할 수 있는 경질공구용합금(스텔라이트 등), 코발트와 탄화텅스텐과 같은 경질 탄화물의 소결(燒結)로 생기는 소결탄화물합금(텅갈로이 등), 영구자석재료 등으로 사용된다. 코발트합금은 고온에서 내산화성·내식성 등이 뛰어나므로 가스터빈 등의 재료로 최근에 그 용도가 많아지고 있다. 그 밖에 화합물은 도자기·유리 등의 착색안료, 도금의 원료, 니스의 건조제 등에 쓰인다.
용도60Co (cobalt-60), a gamma and beta ray emitter with a half-life of about 5.3 years, is used in cancer therapy. Small pieces of radioactive metallic cobalt, made radioactive in a nuclear reactor, are placed into a proper shielding device and the radiation from them used in place of a high-powered x-ray machine or radium implantations in treating patients with localized cancer.
불러오는 중…
Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. Radioactive cobalt damages DNA, RNA, and lipids through ionizing events. (L29)