갈륨 니트레이트
갈륨니트레이트 · ganite · nsc-15200 · Ga(NO3)3nH2O · Ga(NO3)3?5H2O · Wln: ga N-o3*3 · GALLIUM NITRATE · galliumtrinitrate
식별자 및 물리적 특성
| CAS No. | 13494-90-1 |
|---|---|
| 분자식 | GaN3O9 |
| 평균 분자량 | 255.74 g/mol |
| 단동위원소 질량 | 254.88903 g/mol |
| SMILES | O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ga+3] |
| InChIKey | CHPZKNULDCNCBW-UHFFFAOYSA-N |
| PubChem CID | 61635 |
| ChEBI | CHEBI:231505 |
| EC No. | 236-815-5 |
| DTXSID | DTXSID0043923 |
| 현지명 | 갈륨 니트레이트 |
화학 및 물리적 성질
| 극성 표면적 | 189 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 9 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 13 |
| 형식 전하 | 0 |
| 복잡도 | 18 |
| 용해도 | Very soluble (NTP, 1992)soluble in H2O, ethanol, ethyl ether |
| 끓는 점 | 85 |
| 녹는점 | 230 °F (decomposes) (NTP, 1992)110°C (dec.) |
| Physical Description | Gallium nitrate appears as white crystals. (NTP, 1992) |
| 물리적 상태 | 액체 |
| 색상 | white crystals, crystalline powder |
| 용해도 | 물에 용해됩니다. |
| InChI | 1S/Ga.3NO3/c3*2-1(3)4/q+33*-1 |
| InChIKey | CHPZKNULDCNCBW-UHFFFAOYSA-N |
| SMILES | [Ga+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O |
| EPA | Gallium nitrate (13494-90-1) |
화학적 성질
The structural formula of gallium nitrate is Ga(NO3)3. Gallium nitrate is an anhydrate salt that is very soluble in water and soluble in 95% ethanol. It is stable in commonly used intravenous fluids for 14 days at room temperature and at 5 ℃, and physically compatible for injection with selected drug products, with the exception of diazepam injection.This chemical is an oxidizer, and is probably combustible
안전 및 규제
| GHS 분류 | DangerH272 (100%): May intensify fireoxidizer [Danger Oxidizing liquidsOxidizing solids]H314 (10%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H315 (90%): Causes skin irritation [Warning Skin corrosion/irritation]H319 (90%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]H335 (10%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposureRespiratory tract irritation]P210, P220, P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P370+P378, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 10 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. |
|---|---|
| 규제 정보 | Chemical: Nitric acid, gallium salt |
| 운송 라벨(DOT) | Oxidizer |
| 화재 위험 | Flash point data for this chemical are not available, but it is probably combustible. (NTP, 1992) |
| 건강 유해성 | SYMPTOMS: Symptoms of exposure to this compound include nausea, vomiting, renal function depression, proteinuria, normocytic anemia and thrombocytopenia.ACUTE/CHRONIC HAZARDS: This compound is irritating to the skin. It emits toxic fumes when heated to decomposition. (NTP, 1992) |
| 반응성 그룹 | Nitrate and Nitrite Compounds, Inorganic |
| Reactivity Alerts | Strong Oxidizing Agent |
| Reactivity Profile | Oxidizing agents, such as GALLIUM NITRATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water |
용도
개요
Gallium nitrate, initially developed as an anticancer agent, was introduced by Fujisawa as an orphan drug for the treatment of cancer-related hypercalcemia and bone metastases that do not respond to adequate hydration. The compound acts specifically on bone by inhibiting calcium resorption and also possibly by stimulating bone formation. Compared with calcitonin and etidronate, gallium nitrate is more potent and substantially longer acting. Other potential uses could be in the treatment of osteoporosis and Paget’s disease.
용도
Gallium is the second metal ion with clinical activity used in cancer treatment. Gallium nitrate has demonstrated antitumor activity in a variety of murine tumor models, including Walker 256 carcinosarcoma, fibrosarcoma M-89, leukemia K-1964, adenocarcinoma 755, mammary carcinoma YMC, reticulum cell sarcoma A-RCS, lymphoma P1798, and osteosarcoma 124F. It was, however, ineffective in ascites, leukemias, plasma cell tumors, or Ehrlich carcinoma. In phase II evaluation studies, gallium nitrate has shown antitumor activity in patients with either refractory lymphomas or small-cell lung carcinomas or bladder cancer, with total objective response rates of 28% and 11%, respectively. This drug has displayed its strongest antineoplastic activity in the treatment of non-Hodgkin’s lymphoma and bladder cancer. In addition, according to two phase III comparative trials,thanks to an inhibitory effect on calcium reabsorption from bone, gallium nitrate is superior to alternative therapies in the treatment of hypercalcemia associated with malignancy and related disease states. Based on its clinical efficacy, gallium nitrate (Ganite ) was approved by the Food and Drug Administration (FDA) for the treatment of cancerassociated hypercalcemia.Apart from its ability to control hypercalcemia, gallium nitrate has been shown to inhibit bone turnover and decrease osteolysis in patients with multiple myeloma and in patients with bone metastases from a variety of different cancers.
일반 설명
White crystals.