식별자 및 물리적 특성
| CAS No. | 15623-47-9 |
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| 분자식 | Th |
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| 평균 분자량 | 227.0277 g/mol |
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| 단동위원소 질량 | 227.0277 g/mol |
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| SMILES | [227Th] |
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| InChIKey | ZSLUVFAKFWKJRC-FTXFMUIASA-N |
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| PubChem CID | 61806 |
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| DTXSID | DTXSID70891765 |
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화학 및 물리적 성질
| 극성 표면적 | 0 |
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| 수소 결합 공여자 수 | 0 |
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| 수소 결합 수용자 수 | 0 |
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| 회전 가능 결합 수 | 0 |
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| 무거운 원자 수 | 1 |
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| 형식 전하 | 0 |
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| 복잡도 | 0 |
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안전 및 규제
| DOT Hazard Classification | Thorium-227Radioactive materialAtomic number: 90 |
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| Treatment | Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852) |
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| 건강 영향 | Lungs and other internal organs can be penetrated by the alpha radiation produced by thorium. As a result, exposure to an aerosol of thorium can lead to increased risk of cancers of the lung, pancreas and blood. Exposure to thorium internally leads to increased risk of liver diseases. (L1094) |
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| 노출 경로 | Oral (L1838)Inhalation (L1838)Dermal (L1838) |
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| 독성 요약 | The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837) |
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| Signs and Symptoms | Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852) |
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| Carcinogen Classification | 1, carcinogenic to humans. (L135) |
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