기본 정보
- CAS
56391-57-2- 표준 SMILES
CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O.CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
AGFWIZQEWFGATK-UNZHCMSXSA-N- 분자식
- C42H92N10O34S5
- 평균 분자량
- 1,441.6 g/mol
- 단동위원소 질량
- 1,440.4380959
개요
Netilmicin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
이름 및 식별자
- 우선 이름
- Netilmicin Sulfate
- IUPAC
- bis((2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol);sulfuric acid
- 현지명
- NETILMICIN 황산염
- 영어명
- Netilmicin sulfate
- 분자식
- C42H92N10O34S5
- 분자량
- 1441.55
이름 및 동의어
NETILMICIN SULFATE56391-57-2NetromycinNetilmicin SulphateSch 20569Sch-20569S741ZJS97UCHEBI:7529NetromicineNetromicinaNetromycineNetrocin
이름 더 보기
NETILMICIN황산염NETILMICIN황산염(NETILMICINSULFATE)NETILMYCIN SULFATENetililnZetamicinNatimicin sulfateSulfate NetilMicinsulfate(2:5)(salt)Netromycin sulfate1-N-ETHYLSISOMICIN
D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->4))-2-deoxy-N(sup 1)-ethyl-, sulfate (2:5) (salt)DTXCID6025484RefChem:56922Sch20569DTXSID8045484NTL sulfateCertomycinMFCD01311715
데이터베이스 식별자
- CAS
56391-57-2- PubChem CID
- 62115
- ChEMBL
CHEMBL3989829
물성
구조 계산 물성
- 극성 표면적
- 814 Ų
- 수소 결합 공여자 수
- 26
- 수소 결합 수용자 수
- 44
- 회전 가능 결합 수
- 16
- 무거운 원자 수
- 91
- 형식 전하
- 0
- 복잡도
- 754
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 194 °C · >194°C (dec.)
- 끓는 점
- 868 ℃ · 868℃
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 2 O: · H2O: 용해성10mg/mL
- 물리적 상태
- 고체
- 색상
- 흰색에서 희미한 노란색까지
- 수용성
- 물에 용해됨
- 안정성
- 흡습성
- InChIKey
- AGFWIZQEWFGATK-ZHYOXECGNA-N
- EPA
- Netilmicin sulfate (56391-57-2)
화학적 성질
Off-White to Pale Beige Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H312 (73.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 56 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationHazard Traits - Developmental Toxicity
Hazard Classes and CategoriesAcute Tox. 4 (73.2%)
안전 데이터
- wgk
- 3
- rtecs
- WK2286000
- HS 번호
- 2941906000
- risk_code
- 61-20/21/22-60
- hazard_code
- T,Xi
- safety_code
- 53-36/37/39-45-37/39-36-26
- 기존화학 물질
- KE-09606
- Hazard Classifications
- Repr. 1B
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
응용 분야
용도Netilmicin sulfate is used as a broad spectrum antibiotic active against most Gram-negative and some Gram-positive bacteria. It is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but has less ear and kidney toxicity. It is used to treat gram-negative bacterial infections, gonorrhea, skin infections, and other infectious diseases. Since netilmicin sulfate cannot be absorbed from the gut, it can only be administered by injection.
상·하류 제품 정보
상류 원료
공급사100 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
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