여포자극호르몬

개요Gonal-F was launched in Austria, Germany, Denmark, Ireland, Italy, Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The recombinant follicule stimulating hormone (recFSH) was produced by introducing the genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells. The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from contaminants in uroFSH and can be injectable.

용도Follicle stimulating hormone (FSH) from human pituitary has been used for-in vitro luteinization of Macaque granulosa cellsluteal cell proliferation assayculturing of preantral follicle cells obtained from micein vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice andculture of RAW264.7 cell line

일반 설명The α chain of FSHhas 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.