Amoxicillin Trihydrate
AMOXYCILLIN TRIHYDRATE · AMOXICILIN TRIHYDRATE · AmoxiciL · AmoxicillineTrihydrate · AMOXICILLIN TRIHYDRATE IP · Amoxicillin trihydrate for performance verification CRS · Am 7 · A-Gram
식별자 및 물리적 특성
| CAS No. | 61336-70-7 |
|---|---|
| 분자식 | C16H25N3O8S |
| 평균 분자량 | 419.5 g/mol |
| 단동위원소 질량 | 419.13623576 g/mol |
| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O.O.O.O |
| InChIKey | MQXQVCLAUDMCEF-CWLIKTDRSA-N |
| PubChem CID | 62883 |
| ChEBI | CHEBI:51254 |
| EC No. | 612-127-4 |
| DTXSID | DTXSID2022599 |
화학 및 물리적 성질
| 극성 표면적 | 161 |
|---|---|
| 수소 결합 공여자 수 | 7 |
| 수소 결합 수용자 수 | 10 |
| 회전 가능 결합 수 | 4 |
| 무거운 원자 수 | 28 |
| 형식 전하 | 0 |
| 복잡도 | 590 |
| Animal Drugs | Active Ingredients (Amoxicillin Trihydrate) -> FDA GreenbookPharmaceuticals -> UK Veterinary Medicines Directorate List |
| 녹는점 | >200°C (dec.) |
| 굴절률 | 302 ° (C=0.1, H2O) |
| 저장 조건 | Inert atmosphere,2-8°C |
| 용해도 | 물에 약간 용해되고, 에탄올(96%)에 매우 약간 용해되며, 지방유에는 거의 용해되지 않습니다. 묽은 산과 알칼리성 수산화물의 묽은 용액에 용해됩니다. |
| 물리적 상태 | Solid |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | 3.4mg/ml로 물에 용해됩니다. |
| Merck | 14,577 |
| JECFA Number | 85 |
| BRN | 7507120 |
| 주요 응용 | 임상 시험 |
| InChIKey | AIPFZZHNBUVELL-KQLYYQCPNA-N |
| SMILES | C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC(O)=CC=3)N)C(=O)N12)(C)C)(=O)O.O |&1:1,4,6,10,r| |
| EPA | Amoxicillin trihydrate (61336-70-7) |
화학적 성질
White to Off-White Solid
안전 및 규제
| GHS 분류 | DangerH317 (78%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P273, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P391, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 182 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H317 (50%): May cause an allergic skin reaction [Warning Sensitization, Skin] |
|---|---|
| 규제 정보 | Amoxycillin trihydrate: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, trihydrate, [2S-[2.alpha.,5.alpha.,6.beta.(S*)]]-: Environment tier I assessment |
| Hazard Classes and Categories | Skin Sens. 1 (78%)Skin Sens. 1 (50%) |
| 수질 위해 등급(WGK) | 2 |
| RTECS 번호 | XH8300000 |
| 독성 | LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73 |
| 관세 코드 | 29411000 |
| 위험 문구(R) | 42/43 |
| 위험 표시 | Xn,Xi |
| 안전 문구(S) | 36-36/37-22 |
| 위험 등급 | Resp. Sens. 1Skin Sens. 1 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.
용도
Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.