기본 정보
- CAS
91524-16-2- 표준 SMILES
CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1.O- InChIKey
TWBNMYSKRDRHAT-RCWTXCDDSA-N- 분자식
- C26H50N8O7S2
- 평균 분자량
- 650.9 g/mol
- 단동위원소 질량
- 650.32438831
개요
(S)-timolol hemihydrate is a hydrate, which is the hemihydrate form of the (S)-() (more active) enantiomer of timolol. It has a role as a beta-adrenergic antagonist, an antihypertensive agent, an anti-arrhythmia drug and an antiglaucoma drug. It contains a (S)-timolol (anhydrous).
이름 및 식별자
- 우선 이름
- Timolol Hemihydrate
- IUPAC
- bis((2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol);hydrate
- 현지명
- 티몰롤반수화물
- 영어명
- Timolol hemihydrate
- 분자식
- C26H50N8O7S2
- 분자량
- 650.8546
이름 및 동의어
Timolol hemihydrate91524-16-2DTXSID70238611RefChem:933078DTXCID20161102(S)-timolol hemihydrateTimolol (USAN)Timolol [USAN]Betimol (TN)(2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;hydratetimolol.0.5H2OTIMOLOL [VANDF]
이름 더 보기
티몰롤반수화물(-)-S-Timolol(-) S Timolol()STimolol,( ) S Timolol
TIMOLOL [EMA EPAR]SCHEMBL345440TIMOLOL [ORANGE BOOK]TWBNMYSKRDRHAT-RCWTXCDDSA-NTIMOLOL HEMIHYDRATE [VANDF]EBC-80036TIMOLOL HEMIHYDRATE [WHO-DD]DA-68197
데이터베이스 식별자
- CAS
91524-16-2- PubChem CID
- 62933
- DTXSID
DTXSID70238611- ChEBI
CHEBI:60787- UNII
- 817W3C6175
- EC Number
- 691-281-4
물성
구조 계산 물성
- 극성 표면적
- 217 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 17
- 회전 가능 결합 수
- 14
- 무거운 원자 수
- 43
- 형식 전하
- 0
- 복잡도
- 310
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P318, P330, P337+P317, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
약리 정보
FDA Pharmacological Classification
TIMOLOL HEMIHYDRATE
beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
응용 분야
용도Betimol(Sanofi Winthrop).
공급사8 곳
艾吉析科技（上海）有限公司17717235263 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
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