Lidocaine Hydrochloride

LINOCAINE HYDROCHLORIDE · LINOCAINE HCL · Linocaine hydrochlor · Linocaine hydrochloride monohydrate · Lignocaine hydrochloride monohydrate · Linocaine hydrochloride(lidocaine HCL) · 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride hydrate · 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrate hydrochloride

https://huagongshe.com/ko/chemical/6314

식별자 및 물리적 특성

CAS No.	6108-05-0
분자식	C14H23ClN2O
평균 분자량	270.8 g/mol
단동위원소 질량	270.14989104 g/mol
SMILES	CCN(CC)CC(=O)Nc1c(C)cccc1C.Cl
InChIKey	IYBQHJMYDGVZRY-UHFFFAOYSA-N
PubChem CID	6314
ChEMBL	CHEMBL1200409
EC No.	200-803-8
DTXSID	DTXSID4058782

화학 및 물리적 성질

극성 표면적	32.3
수소 결합 공여자 수	2
수소 결합 수용자 수	2
회전 가능 결합 수	5
무거운 원자 수	18
형식 전하	0
복잡도	228
Human Drugs	Breast FeedingLactationMilk, HumanAntiarrhythmicsLocal AnestheticsFDA approved drugs -> Active ingredient
Collision Cross Section	155.4 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
녹는점	75-79℃
저장 조건	2-8°C
용해도	H2O: 용해성
물리적 상태	고체
색상	하얀색
용해도	물(50 mg/ml), 클로로포름, 에탄올 및 벤젠에 용해됩니다. 디에틸 에테르에 불용성.
주요 응용	의약품(소분자)
InChI	InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)1H1H2
InChIKey	YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES	C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl
LogP(분배 계수)	2.359 (est)

화학적 성질

Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.

안전 및 규제

GHS 분류	DangerH301 (82.5%): Toxic if swallowed [Danger Acute toxicity, oral]P264, P270, P301+P316, P301+P317, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 183 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H301 (46.3%): Toxic if swallowed [Danger Acute toxicity, oral]
규제 정보	Lidocaine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, monohydrochloride: Environment tier I assessment
Hazard Classes and Categories	Acute Tox. 3 (46.3%)Acute Tox. 3 (82.5%)
Treatment	The first step in the management of systemic toxic reactions consists of immediate attention to the establishment and maintenance of a patent airway and assisted or controlled ventilation with oxygen and a delivery system capable of permitting immediate positive airway pressure by mask. If convulsions occur, the objective of the treatment is to maintain ventilation and oxygenation and support the circulation. Oxygen must be given and ventilation assisted if necessary (mask and bag or tracheal intubation). Should convulsions not stop spontaneously after 15-20 seconds, an anticonvulsant should be given i.v. to facilitate adequate ventilation and oxygenation. Thiopental sodium 1-3 mg/kg i.v. is the first choice. Alternatively diazepam 0.1 mg/kg bw i.v. may be used, although its action will be slow. Prolonged convulsions may jeopardise the patient's ventilation and oxygenation. If so, injection of a muscle relaxant (e.g. succinylcholine 1 mg/kg bw) will facilitate ventilation, and oxygenation can be controlled. Early endotracheal intubation must be considered in such situations. If cardiovascular depression is evident (hypotension, bradycardia), ephedrine 5-10 mg i.v. should be given and may be repeated, if necessary, after 2-3 minutes. Should circulatory arrest occur, immediate cardiopulmonary resuscitation should be instituted. Continual oxygenation and ventilation and circulatory support as well as treatment of acidosis are of vital importance. (L1712)
건강 영향	Systemic exposure to excessive quantities of lidocaine mainly result in central nervous system (CNS) and cardiovascular effects. CNS effects may include CNS excitation(nervousness, tingling around the mouth) followed by depression. [Wikipedia]

용도

Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.