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기본 정보
- CAS
112362-50-2- 표준 SMILES
CCN(CC)CCS(=O)(=O)[C@@H]1CCN2C(=O)c3coc(n3)CC(=O)C[C@H](O)/C=C(C)/C=C/CNC(=O)/C=C/[C@@H](C)[C@@H](C(C)C)OC(=O)[C@@H]12- InChIKey
SUYRLXYYZQTJHF-VMBLUXKRSA-N- 분자식
- C34H50N4O9S
- 평균 분자량
- 690.86 g/mol
- 단동위원소 질량
- 690.32985018
이름 및 식별자
- 우선 이름
- Dalfopristin
- IUPAC
- (3R,4R,5E,10E,12E,14S,26R,26aS)-26-[2-(Diethylamino)ethanesulfonyl]-14-hydroxy-4,12-dimethyl-3-(propan-2-yl)-8,9,14,15,24,25,26,26a-octahydro-1H,3H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
- 현지명
- 달포프리스틴
- 영어명
- Dalfopristin
- 분자식
- C34H50N4O9S
- 분자량
- 690.85
이름 및 동의어
달포프리스틴RP 54476DalfopristinDalfopristin MesylateDalfopristin (RP54476)Dalfopristin (as mesylate)Dalfopristin, 10 mM in DMSORP-54476,RP 54476,Inhibitor,Dalfopristin,Antibiotic,Bacterial,inhibit(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadi(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(DiethylaMino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-diMethyl-3-(1-Methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetr(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
데이터베이스 식별자
- CAS
112362-50-2
물성
물리화학적 성질
- 녹는점
- 150 ° · ~150°
- 끓는 점
- 940.5 · 940.5±65.0 °C(Predicted)
- 밀도
- 1.27 · 1.27±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 113 · DMSO:113.0(Max Conc. mg/mL);163.57(Max Conc. mM)Ethanol:100.0(Max Conc. mg/mL);144.75(Max Conc. mM)
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 13.18 · 13.18±0.70(Predicted)
- 색상
- White to yellow
- Henry's Law Constant
- 2.2 · 2.2×1024 mol/(m3Pa) at 25℃, HSDB (2015)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 유해 물질 데이터
- 112362-50-2(Hazardous Substances Data)
화학 및 산업
응용 분야
용도Dalfopristin is a semi-synthetic analogue of ostreogyrcin A (virginiamycin M, pristinamycin IIA, streptogramin A) formed by addition of diethylaminoethylthiol to the 2-pyrroline group of ostreogyrcin, followed by oxidation to the sulphone. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Dalfopristin is used commercially in synergistic combination with quinupristin (70:30). There is little published data on the synthesis, biological or antibiotic activity of dalfopristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.
공급사60 곳
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