아연 피리치온
아연피리치온 · 징크피리치온 · 징크피리티온 · ZPT · Pyrithione zinc · ZNPT · 1-HYDROXYPYRIDINE-2-THIONE ZINC · Bis[[(pyridine 1-oxide)-2-yl]thio] zinc salt
식별자 및 물리적 특성
| CAS No. | 13463-41-7 |
|---|---|
| 분자식 | C10H8N2O2S2Zn |
| 평균 분자량 | 317.71 g/mol |
| SMILES | O[N+]1=CC=CCC1=S.On1ccccc1=S.[Zn] |
| PubChem CID | 6327770 |
| 현지명 | 아연 피리치온 |
화학 및 물리적 성질
| 녹는점 | approximate 240℃ |
|---|---|
| 밀도 | 1.782 g/cm3(Temp: 25 °C) |
| 증기압 | 0Pa at 25℃ |
| 저장 조건 | Sealed in dry,Room Temperature |
| 용해도 | almost transparency in Pyridine |
| 물리적 상태 | 가루 |
| 색상 | White to Orange to Green |
| 냄새 | 온화한 특유의 냄새 |
| 용해도 | 불용성(21°C에서 <0.1g/100mL) |
| Merck | 14,7994 |
| 화장품 원료 기능 | 항균 방부제헤어 컨디셔닝항지루성피지 억제 |
| InChI | InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8/h2*1-4,8H/q+2/p-2 |
| InChIKey | OTPSWLRZXRHDNX-UHFFFAOYSA-L |
| SMILES | C1(C=CC=C[N+]=1[O-])S[Zn]SC1C=CC=C[N+]=1[O-] |
| LogP(분배 계수) | 0.9 at 25℃ and pH7.5-7.7 |
| 표면장력 | 73mN/m at 7.22mg/L and 20℃ |
| EPA | Zinc pyrithione (13463-41-7) |
화학적 성질
Beige granules
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | ZH0950000 |
| 운송 번호(UN) | UN 2811 6.1/PG 2 |
| 독성 | LD50 oral in rat: 177mg/kg |
| 관세 코드 | 29333990 |
| 위험 문구(R) | 24/25-26-37/38-41-50/53-23-22 |
| 위험 표시 | T+,N,T |
| 안전 문구(S) | 26-28-36/37/39-45-61-60-39 |
| 포장분류 | III |
| 위험 등급 | 6.1(b)Acute Tox. 2 InhalationAcute Tox. 3 OralAquatic Acute 1Aquatic Chronic 1Eye Dam. 1Repr. 1BSTOT RE 1 |
| 기존화학 물질 | KE-35577 |
| 저장 분류 | 6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials |
| 유해 물질 데이터 | 13463-41-7(Hazardous Substances Data) |
| 함량 및 규제정보 | 물질구분: 유독물질혼합물(제품)함량정보: 피리치온 구리[Copper pyrithione2-Pyridinethiol, 1-oxide, copper salt14915-37-8], 피리치온 아연[Zinc pyrithione2-Pyridinethiol 1-oxide zinc salt13463-41-7] 및 이를 1% 이상 함유한 혼합물 |
| 유해화학물질 필터링 | 2022-1-1089 |
용도
개요
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, E. faecium, E. faecalis, and E. cloacae (MICs = 1-4 μg/ml) and the fungus P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
용도
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks. Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
일반 설명
Fine beige granules.