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깁사이트(Al(OH)3)

Alhydrogel

HCID 6328211
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
14762-49-3
표준 SMILES
O.O.O.[Al]
InChIKey
MXRIRQGCELJRSN-UHFFFAOYSA-N
분자식
AlH6O3
평균 분자량
81.028 g/mol
단동위원소 질량
81.0132325

개요

Aluminium hydroxide is a member of aluminium hydroxides. It has a role as an antacid and a flame retardant.

이름 및 식별자

우선 이름
Alhydrogel
현지명
깁사이트(Al(OH)3)
영어명
Gibbsite (Al(OH)3)
분자식
AlH3O3
분자량
78

이름 및 동의어

RefChem:556672TricreamalateAscriptinCalcitrelTrisogelKudroxMaaloxMaalox PlusSimeco SuspensionDi-Gel LiquidAKP-DA14762-49-3
이름 더 보기
깁사이트(Al(OH)3)hydrargiliteGibbsite (AI(OH)3)alpha-aluminum hydroxide
Gibbsite (Al(OH)3)C 4dHSDB 575Aluminum hydroxide (Al(OH)3)EINECS 244-492-7UNII-5QB0T2IUN0Arthritis Pain Formula Maximum StrengthC 31

데이터베이스 식별자

CAS
14762-49-3、21645-51-2
PubChem CID
6328211
ChEMBL
CHEMBL1200706
ChEBI
CHEBI:33130

물성

구조 계산 물성

극성 표면적
3 Ų
수소 결합 공여자 수
3
수소 결합 수용자 수
3
회전 가능 결합 수
0
무거운 원자 수
4
형식 전하
0
복잡도
3.2

실험 및 물리화학적 성질

Polymers · 3건

Plastics -> Flame retardants

Plastics -> Other functions -> Pigment

Plastics -> Polyolefin-I; PUR; PA

Flame RetardantsFlame retardants

물리화학적 성질

밀도
2.441 · monocl: 2.441; tricl: 2.42 [KIR78] [ROB78]
녹는점
165 °C · 165 °C (decomp)
InChI
InChI=1S/Al.3H2O/h;3*1H2/q+3;;;/p-3
InChIKey
WNROFYMDJYEPJX-UHFFFAOYSA-K
SMILES
[Al](O)(O)O

화학적 성질

white, pearly vitreous; hardness 2.5–3.5 Mohs; monocl: a=0.868 nm, b=0.507 nm, c=0.972 nm; tricl: a=1.733nm, b=1.008nm, c=0.973 nm [KIR78]

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

유해성 정보

Regulatory Information · 2건

Chemical: Gibbsite (Al(OH)3)

Gibbsite (Al(OH)3): Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Other Safety InformationIMAP assessments - Gibbsite (Al(OH)3): Human health tier I assessment

안전 및 보호

Minimum Risk LevelIntermediate Oral: 1.0 mg/kg/day (L134) Chronic Oral: 1.0 mg/kg/day (L134)

독성 정보

Treatment · 1건

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1건

Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740)

Exposure RoutesOral (L739) ; inhalation (L739)

화학 및 산업

약리 정보

Metabolism/Metabolites · 1건

Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (L739)

MeSH Pharmacological Classification · 2건

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.

용도 및 제조

Uses · 2건

Plastics -> Typical concentration range in plastic materials -> 0.25 - 50.0%

Aluminium hydroxide is used as an antacid and included as an adjuvant in some vaccines. (L756)

Use Classification · 3건

Plastics -> Other functions -> Pigment

Plastics -> Polymer Type -> Polyolefin-I; PUR; PA

Plastics -> Flame retardants

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
Toxicity Summary · 1건

The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. It has been suggested that aluminum's interaction with estrogen receptors increases the expression of estrogen-related genes and thereby contributes to the progression of breast cancer (A235), but studies have not been able to establish a clear link between aluminum and increased risk of breast cancer (A15468). Certain aluminum salts induce immune responses by activating inflammasomes. (L739, A235, A236)

Signs and Symptoms · 1건

Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (L739, L740)

Carcinogen Classification · 1건

Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468).

Toxicity DataLD50: 1100 mg/kg (Intraperitoneal, Rat) (L757) LD50: >5000 mg/kg (Oral, Rat) (A554)

공급사18 곳

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