아만사틴 하이드로클로라이드

아만사틴하이드로클로라이드 · AMANTADINE HCL · AMANTADINE HYDROCHLORIDE · 1-AMINOADAMANTANE HYDROCHLORIDE · ADAMANTANAMINE HYDROCHLORIDE · symmetrel · 1-ADAMANTANAMINE HCL · ADAMANTAN-1-AMINE HYDROCHLORIDE

https://huagongshe.com/ko/chemical/64150

식별자 및 물리적 특성

CAS No.	665-66-7
분자식	C10H17N.ClH
평균 분자량	187.71 g/mol
단동위원소 질량	187.11277726 g/mol
SMILES	Cl.NC12CC3CC(CC(C3)C1)C2
InChIKey	WOLHOYHSEKDWQH-UHFFFAOYSA-N
PubChem CID	64150
ChEMBL	CHEMBL1569
EC No.	211-560-2
DTXSID	DTXSID50874031
현지명	아만사틴 하이드로클로라이드

화학 및 물리적 성질

극성 표면적	26
수소 결합 공여자 수	2
수소 결합 수용자 수	1
회전 가능 결합 수	0
무거운 원자 수	12
형식 전하	0
복잡도	144
Human Drugs	Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntiparkinson AgentsAntiviral AgentsDopamine AgentsFDA approved drugs -> Active ingredient
Physical Description	Dry Powder
Collision Cross Section	138.6 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
녹는점	>300 °C(lit.)
끓는 점	308.63°C (rough estimate)
밀도	1.0276 (rough estimate)
굴절률	1.6100 (estimate)
저장 조건	Store below +30°C.
용해도	H2O: 50 mg/mL
물리적 상태	미세 결정성 분말
pKa(산도 계수)	10.71
색상	하얀색
용해도	녹는
Merck	14,374
BRN	4198854
주요 응용	의약품(소분자)
InChI	1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H21H/t7-,8+,9-,10-
InChIKey	WOLHOYHSEKDWQH-UHFFFAOYSA-N
SMILES	Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
LogP(분배 계수)	-1.64 at 23℃ and pH6.3
EPA	Amantadine hydrochloride (665-66-7)

화학적 성질

Crystalline Solid

안전 및 규제

GHS 분류	DangerH302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P363, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 210 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Chemical: Tricyclo[3.3.1.13,7]decan-1-amine, hydrochlorideHazard Traits - Developmental ToxicityTricyclo[3.3.1.13,7]decan-1-amine, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Tricyclo[3.3.1.13,7]decan-1-amine, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)REACH registered substance: Amantadine hydrochloride (EC: 211-560-2)1-Adamantane ammonium chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories	Acute Tox. 4 (99.5%)
Treatment	There is no specific antidote for an overdose of Amantadine. However, slowly administered intravenous physostigmine in 1 and 2 mg doses in an adult2 at 1- to 2-hour intervals and 0.5 mg doses in a child3 at 5- to 10-minute intervals up to a maximum of 2 mg/hour have been reported to be effective in the control of central nervous system toxicity caused by amantadine hydrochloride. For acute overdosing, general supportive measures should be employed along with immediate gastric lavage or induction of emesis. Fluids should be forced, and if necessary, given intravenously. The pH of the urine has been reported to influence the excretion rate of Amantadine. (L1744)
건강 영향	Acute overdosage of amantadine has resulted in cardiac dysfunction (e.g., arrhythmia, tachycardia, hypertension)pulmonary edema and respiratory distress (including adult respiratory distress syndrome)renal dysfunction (e.g., increased BUN, decreased creatinine clearance, renal insufficiency)or CNS toxicity (e.g., insomnia, anxiety, psychotic reactions, lethargy, somnolence, coma). Hyperthermia also has occurred with amantadine overdosage. In addition, seizures may be exacerbated in patients with a history of a seizure disorder (A620).

용도

1-Adamantanamine hydrochloride is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extra pyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.

일반 설명

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards