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시클리진염산염(200MG)

Cyclizine Hydrochloride

HCID 6420019
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
303-25-3
표준 SMILES
CN1CCN(C(c2ccccc2)c2ccccc2)CC1.Cl
InChIKey
UKPBEPCQTDRZSE-UHFFFAOYSA-N
분자식
C18H23ClN2
평균 분자량
302.8 g/mol

개요

Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a central nervous system depressant, a H1-receptor antagonist, a cholinergic antagonist and an antiemetic. It contains a cyclizine.

이름 및 식별자

우선 이름
Cyclizine Hydrochloride
IUPAC
1-benzhydryl-4-methylpiperazine;hydrochloride
현지명
시클리진염산염(200MG)
영어명
Cyclizine Hydrochloride
분자식
C18H23ClN2
분자량
302.84162

이름 및 동의어

Cyclizine hydrochloride303-25-3CYCLIZINE HClMarezine hydrochloride1-(diphenylmethyl)-4-methylpiperazine hydrochlorideValoidColloxW0O1NHP4WE1-(Diphenylmethyl)-4-methylpiperazine monohydrochlorideNSC-169102(+-)-1-Diphenylmethyl-4-methylpiperazine hydrochloridePiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride
이름 더 보기
시클리진염산염(200MG)Cyclizine HCl solutionEchnatolFortravelCYCLYZINE HCLEinecs 206-136-9cyclizinechloridemarezinehydrochlorideCyclizini hydrochloridum
CHEBI:51045NSC169102DTXCID2027753ValiodHCl, CyclizineHydrochloride, CyclizineRefChem:919340206-136-9

데이터베이스 식별자

CAS
303-25-3
PubChem CID

물성

구조 계산 물성

극성 표면적
6.5 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
2
회전 가능 결합 수
3
무거운 원자 수
21
형식 전하
0
복잡도
253

실험 및 물리화학적 성질

Human DrugsBreast Feeding; Lactation; Antiemetics; Antihistamines; Anti-Allergic Agents; Gastrointestinal Agents

물리화학적 성질

녹는점
258 · 258-260℃
끓는 점
457.04 °C · 457.04°C (rough estimate)
밀도
1.0551 · 1.0551 (rough estimate)
굴절률
1.5749 · 1.5749 (estimate)
저장 조건
Refrigerator
용해도
1 mg/ml · Methanol: 1 mg/ml
물리적 상태
solid
주요 응용
제약소분자 약용
InChI
1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
InChIKey
UKPBEPCQTDRZSE-UHFFFAOYSA-N
SMILES
[Cl-].N3(CCN(CC3)C)C(c2ccccc2)c1ccccc1.[H+]

화학적 성질

Off-White Solidmoderately soluble in water

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P320, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Regulatory InformationPiperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Piperazine, 1-(diphenylmethyl)-4-methyl-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 3 (100%)

독성 정보

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

wgk
3
ridadr
3249
독성
mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
HS 번호
2933595960
risk_code
61-23/24/25-42/43
hazard_code
T

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Drugs used to prevent NAUSEA or VOMITING.

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.

응용 분야

용도Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.

상·하류 제품 정보

상류 원료

벤즈히드릴클로라이드N-메틸피페라진

공급사56 곳

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LIDE PHARMACEUTICALS LIMITED+852-55945652 · [email protected]
上海策嵘生物科技有限公司[email protected]
Career Henan Chemica Co

관련 반응

1건
반응 기록 만들기
HRID 749412 반응식
HRID 749412반응물로uspto-grants-2008_07

화합물 노트

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6420019
ChEMBL
CHEMBL1324714
ChEBI
CHEBI:51045
UNII
W0O1NHP4WE
EC Number
206-136-9
safety_code
53-22-36/37/39-45
포장분류
III
위험 등급
6.1(b)
Hazard Classifications
Acute Tox. 3 Oral
스토리지 클래스
6.1A - Combustible acute toxic Cat. 1 and 2very toxic hazardous materials
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추가 설명 · 1건

정의ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.