트라이엠시놀론아세토나이드
트라이엠시놀론아세토나이드 · TRIAMCINOLONE ACETONIDE ACETATE · Refrigerator · Triam · KENALOG · Triamsinolone acetonide · Triamcinolone acetonide CRS · Fluocinolone Acetonide EP Impurity H
식별자 및 물리적 특성
| CAS No. | 76-25-5 |
|---|---|
| 분자식 | C24H31FO6 |
| 평균 분자량 | 434.5 g/mol |
| 단동위원소 질량 | 434.21046693 g/mol |
| SMILES | CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1 |
| InChIKey | YNDXUCZADRHECN-JNQJZLCISA-N |
| PubChem CID | 6436 |
| ChEMBL | CHEMBL1504 |
| ChEBI | CHEBI:71418 |
| EC No. | 200-948-7 |
| DTXSID | DTXSID6021371 |
| 현지명 | 트라이엠시놀론아세토나이드 |
화학 및 물리적 성질
| XLogP | 2.5 |
|---|---|
| 극성 표면적 | 93.1 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 7 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 31 |
| 형식 전하 | 0 |
| 복잡도 | 925 |
| 의약품 | Pharmaceuticals -> Dermatologicals -> Corticosteroids, dermatological preparations |
| LogP(분배 계수) | 2.53 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| Animal Drugs | Active Ingredients (Triamcinolone Acetonide) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Collision Cross Section | 290.1 Ų [M+H]+ [CCS Type: DTBuffer gas: N2Ionization: ESI+Dataset: TOXCASTSource Identifier: DTXSID6021371]197.1 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| 녹는점 | 274-278°C (dec.) |
| 끓는 점 | 576.9±50.0 °C(Predicted) |
| 밀도 | 1.1517 (estimate) |
| 굴절률 | 1.5980 (estimate) |
| 저장 조건 | Refrigerator |
| 용해도 | 물에는 거의 녹지 않으며, 에탄올에는 거의 녹지 않습니다(96%). |
| pKa(산도 계수) | 12.87±0.10(Predicted) |
| 물리적 상태 | Solid |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | DMSO 또는 에탄올에 용해됩니다. 물에 약간 용해됩니다. |
| Merck | 9596 |
| BCS Class | 4 |
| 안정성 | 타기 쉬운. 강한 산화제와 호환되지 않습니다. |
| InChIKey | YNDXUCZADRHECN-JNQJZLCISA-N |
| NIST | Triamcinolone acetonide(76-25-5) |
| EPA | Triamcinolone acetonide (76-25-5) |
화학적 성질
White Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 1.8% (1 of 55) of reports.DangerH302 (12.7%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P264, P270, P280, P301+P317, P318, P319, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 55 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Triamcinolone acetonide: Non hazardous |
| 기타 안전 정보 | IMAP assessments - Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11.beta.,16.alpha.)-: Human health tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (12.7%) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | TU3920000 |
| 독성 | LD50 oral in mouse: 5gm/kg |
| 관세 코드 | 29372290 |
| 위험 문구(R) | 61 |
| 위험 표시 | T |
| 안전 문구(S) | 53-45 |
용도
개요
Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model when used at a dose of 1.5 mg/kg prior to and following surgery for three days. Triamcinolone acetonide also decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 μl of a 40 mg/ml suspension is administered subconjunctivally. Formulations containing triamcinolone acetonide are used in the treatment of diabetic macular edema.
일반 설명
The three main metabolitesof triamcinolone acetonide (Azmacort, Nasacort) are 6β-hydroxytriamcinolone acetonide, 21-carboxytriamcinoloneacetonide, and 6β-hydroxy-21-carboxytriamcinolone acetonide.All are much less active than the parent compound.The 6β-hydroxyl group and the 21-carboxy group are bothstructural features that greatly reduce GC action. The increasedwater solubility of these metabolites also facilitatesmore rapid excretion.