Tylosin phosphate

Tylosin phosphate (TS) is a light yellow to yellow liquid substance with a characteristic odor. Tylosin phosphate has an antibacterial effect mainly on Gram-positive bacteria and partly on Gramnegative bacteria and mycoplasma, and has a growth-promoting effect on pigs.

역사Tylosin phosphate is a macrolide antibiotic that was isolated and identified in 1959 by American scientists McGuire, Hamill, et al. from the fermentation broth of Streptomyces fradiae. As a secondary metabolite of this bacterium, it was subsequently produced industrially via fermentation by Eli Lilly and Company in Indiana, USA. The phosphate and tartrate salts of tylosin are currently the most commonly used forms in clinical practice. Although tylosin can also be produced by other bacterial strains, such as Streptomyces rimosus and Streptomyces hygroscopicus, Streptomyces fradiae remains the preferred strain for its industrial fermentation production.

용도Tylosin phosphate is a pure-grade antibiotic that was designated as a feed additive as of July 24, 1976. It is used for prevention and control of chronic respiratory disease (CRD) in replacement pullets, broilers, increasing bodyweight and improvement of feed conversion rate in broilers, increasing egg production.

일반 설명Tylosin phosphate is an antibacterial agent employed against mycoplasma organisms. It is only used in veterinary field and effective basically against gram positive bacteria, but also has efficacy against some spirochetes and gram negatives (except coliforms). Tylosin phosphate, marketed as Tylan 40 or Tylan 100 Type A medicated article, is approved for use in beef cattle to reduce the incidence of liver abscesses caused by Fusobacterium necrophorum and Arcanobacterium (Actinomyces) pyogenes.