Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 6442739생성일: 2026년 10월 26일
(5Z,8Z,11Z,14Z)-16-Hydroxy-5,8,11,14-eicosatetraenoic acid
16-HETE · (±)16-HETE · JEKNPVYFNMZRJG-UFINWASNSA-N · (±)16-HETE, CAS 128914-46-5 · 16-hydroxy-5(Z),8(Z),11(Z),14(Z)-ETA · 16-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid · 5,8,11,14-Eicosatetraenoic acid, 16-hydroxy-, (5Z,8Z,11Z,14Z)-
https://huagongshe.com/ko/chemical/6442739
식별자 및 물리적 특성
| CAS No. | 128914-46-5 |
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| 분자식 | C20H32O3 |
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| 평균 분자량 | 320.5 g/mol |
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| 단동위원소 질량 | 320.23514488 g/mol |
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| SMILES | CCCCC(O)/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O |
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| InChIKey | JEKNPVYFNMZRJG-UFINWASNSA-N |
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| PubChem CID | 6442739 |
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| ChEBI | CHEBI:63994 |
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| DTXSID | DTXSID501192263 |
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화학 및 물리적 성질
| XLogP | 4.8 |
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| 극성 표면적 | 57.5 |
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| 수소 결합 공여자 수 | 2 |
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| 수소 결합 수용자 수 | 3 |
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| 회전 가능 결합 수 | 14 |
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| 무거운 원자 수 | 23 |
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| 형식 전하 | 0 |
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| 복잡도 | 392 |
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| 지질 | Fatty Acyls [FA] -> Eicosanoids [FA03] -> Hydroxy/hydroperoxyeicosatetraenoic acids [FA0306] |
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| Collision Cross Section | 183.4 Ų [M-H]- [CCS Type: DTBuffer gas: N2Ionization: ESI-Calculation: Single FieldDataset: Oxylipins] |
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| 끓는 점 | 477.276±45.00 °C(Press: 760.00 Torr)(predicted) |
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| 밀도 | 0.984±0.06 g/cm3(Temp: 25 °CPress: 760 Torr)(predicted) |
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| 저장 조건 | Store at -20°C |
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| 용해도 | 0.1 M Na2CO3: 2 mg/mlDMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS (pH 7.2): 0.8 mg/ml |
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| pKa(산도 계수) | 4.752±0.10(predicted) |
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용도
개요
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
