Eprodisate Disodium

HCID 6451143CAS 36589-58-9

기본 정보

표준 SMILES: O=S(=O)([O-])CCCS(=O)(=O)[O-].[Na+].[Na+]
InChIKey: DKGJFKPIUSHDIT-UHFFFAOYSA-L
분자식: C3H6Na2O6S2
평균 분자량: 248.2 g/mol
단동위원소 질량: 247.94011847

개요

Eprodisate Disodium is the orally available disodium salt form of eprodisate, a negatively charged sulfonated inhibitor of fibrillogenesis, that can be used in the treatment of amyloid A (AA) amyloidosis. Upon administration, eprodisate competitively binds to the glycosaminoglycan binding sites on serum amyloid A (SAA), which inhibits the formation of the glycosaminoglycan-amyloid fibril aggregate. This prevents the formation of amyloid deposits in certain organs, especially the kidneys, in AA amyloidosis.

이름 및 식별자

우선 이름: Eprodisate Disodium
IUPAC: disodium;propane-1,3-disulfonate

이름 및 동의어

Eprodisate disodium36589-58-9KiactaDisodium propane-1,3-disulfonateEprodisate sodium1,3-Propanedisulfonic acid, disodium saltNC-503Eprodisate Disodium [USAN]UNII-5X0D9H16IUNC 5035X0D9H16IUDTXSID9046732

이름 더 보기

DISODIUM EPRODISATENSC-240395NSC-760403Eprodisate disodium (USAN)DTXCID7026732EPRODISATE DISODIUM [MART.]EPRODISATE DISODIUM [WHO-DD]NSC 240395

데이터베이스 식별자

CAS: 36589-58-9
PubChem CID: 6451143
DTXSID: DTXSID9046732
ChEMBL: CHEMBL2107338
UNII: 5X0D9H16IU
EC Number: 621-789-3
Nikkaji: J534.156F

물성

구조 계산 물성

극성 표면적: 131 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 6
회전 가능 결합 수: 2
무거운 원자 수: 13
형식 전하: 0
복잡도: 227

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.