Trityl chloride (HCID 6456)

이름 및 식별자

우선 이름: Trityl chloride
IUPAC: [chloro(diphenyl)methyl]benzene
현지명: 트리틸클로라이드
영어명: Triphenylmethyl Chloride
분자식: C19H15Cl
분자량: 278.78

이름 및 동의어

Trityl chloride76-83-5TriphenylchloromethaneCHLOROTRIPHENYLMETHANEMethane, chlorotriphenyl-triphenylmethylchlorideBenzene, 1,1',1''-(chloromethylidyne)tris-DTXSID30525111,1',1''-(Chloromethylidyne)trisbenzene1D9GZ8QQXNNSC-435DTXCID7031084

이름 더 보기

트리틸클로라이드트리페닐클로로메탄트리페닐클로로메탄TRT-CLTRITY CHLORIDETRIPHENYLCHLORMETHANEchlorotriphenyl-methanNSC 435

RefChem:575983200-986-4Triphenylmethyl chloride(chloromethanetriyl)tribenzene(chlorodiphenylmethyl)benzeneTrityl Chloride Resin[Chloro(diphenyl)methyl]benzeneC19H15Cl

데이터베이스 식별자

CAS: 76-83-5
PubChem CID: 6456
DTXSID: DTXSID3052511
ChEMBL: CHEMBL261393
UNII: 1D9GZ8QQXN
EC Number: 200-986-4
Nikkaji: J62.557D

물성

구조 계산 물성

XLogP: 5
극성 표면적: 0 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 0
회전 가능 결합 수: 3
무거운 원자 수: 20
형식 전하: 0
복잡도: 235

실험 및 물리화학적 성질

Color/FormNEEDLES OR PRISMS FROM BENZENE OR PETROLEUM ETHER

SolubilityINSOL IN WATER, SLIGHTLY SOL IN ALCOHOL, SOL IN ACETONE; VERY SOL IN ETHER, BENZENE, CHLOROFORM, CARBON DISULFIDE, CARBON TETRACHLORIDE

Boiling Point310 °C @ 760 MM HG

Melting Point113-114 °C

Vapor Pressure0.00000387 [mmHg]

Physical DescriptionSolid; [HSDB] Off-white powder with a pungent odor; Hydrolyzed with water; [MSDSonline]

물리화학적 성질

녹는점: 109 · 109-112 °C(lit.)
끓는 점: 230 · 230-235 °C20 mm Hg(lit.)
밀도: 1.1088 · 1.1088 (rough estimate)
굴절률: 1.6281 · 1.6281 (estimate)
인화점: 230 · 230-235°C/20mm
저장 조건: 30 °C · Store below +30°C.
용해도: 0.1 g/mL, · 클로로포름: 0.1 g/mL, 투명
물리적 상태: 분말 또는 결정
색상: 흰색에서 회백색 또는 연한 노란색-베이지색
수용성: 물에 불용성. 클로로포름, 헥산, 벤젠, 에테르, 아세톤 및 테트라히드로푸란에 용해됩니다.
BRN: 397363 · 397363
InChI: 1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
InChIKey: JBWKIWSBJXDJDT-UHFFFAOYSA-N
SMILES: ClC(c1ccccc1)(c2ccccc2)c3ccccc3
NIST: Triphenylmethyl chloride(76-83-5)
EPA: Chlorotriphenylmethane (76-83-5)

화학적 성질 · 1건

Triphenylmethyl chloride or trityl chloride (TrCl) is a white to yellow solid. Insoluble in water, easily soluble in benzene, carbon disulfide, petroleum ether, slightly soluble in alcohol and ether, and becomes trityl alcohol after absorbing water. It is an alkyl halide, sometimes used to introduce the trityl protecting group.

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H314 (77.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (22.6%): Causes skin irritation [Warning Skin corrosion/irritation]；H318 (28.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H335 (40.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H400 (41.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (43.1%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P260, P261, P264, P264+P265, P271, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P321, P332+P317, P362+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 137 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 3건

Chemical: Benzene, 1,1',1''-(chloromethylidyne)tris-

Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18906

Chlorotriphenylmethane: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryA corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]

Hazard Classes and CategoriesSkin Corr. 1B (77.4%)；Skin Irrit. 2 (22.6%)；Eye Dam. 1 (28.5%)；STOT SE 3 (40.9%)；Aquatic Acute 1 (41.6%)；Aquatic Chronic 1 (43.1%)

독성 정보

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

Non-Human Toxicity Excerpts · 1건

POTENCY OF TRIPHENYL DERIV OF GROUP IV ELEMENTS IN INHIBITING GROWTH OF 1ST & 4TH INSTAR T CASTANEUM LARVAE WAS MUCH GREATER FOR PH3SNCL & PH3PBCL THAN FOR PH3CCL. IN HIGH CONCN PH3CCL WAS INACTIVE IN INHIBITING IN VITRO INVERTASE, AMYLASE & PROTEASE ACTIVITIES.

규제 정보

Regulatory Information · 3건

Chemical: Benzene, 1,1',1''-(chloromethylidyne)tris-

Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/18906

Chlorotriphenylmethane: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 3
tsca: TSCA listed
rtecs: PA6450000
ridadr: UN 3261 8/PG 3
독성: LD50 orally in Rabbit: > 5000 mg/kg
HS 번호: 29036990
risk_code: 34-50/53-14-36/37
hazard_code: C,N
safety_code: 26-36/37/39-45-61-27
포장분류: III
위험 등급: 8
기존화학 물질: KE-05735
F 고인화성물질: 10-19-21
위험 참고 사항: Irritant
Hazard Classifications: Skin Corr. 1B
스토리지 클래스: 8A - Combustible corrosive hazardous materials
유해 물질 데이터: 76-83-5(Hazardous Substances Data)

화학 및 산업

용도 및 제조

General Manufacturing Information · 2건

Benzene, 1,1',1''-(chloromethylidyne)tris-: ACTIVE

TRIARYL CHLOROALKANE IMPROVED ADHESION OF FAST-SETTING POLYURETHANE PREPOLYMER TO TISSUE.

응용 분야 · 2건

용도본제품은 의약화공 영역에서 상용하는 기본유기원료 중 하나이다.

용도Trityl Chloride is an alkyl halide commonly used in organic synthesis to introduce the trityl protecting group. Trityl Chloride is used in the preparation of S-trityl-L-cysteine (STLC), a tight-bindin g inhibitor of Eg5 that prevents mitotic progression.