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PH (1 IN 100 SOLN) BETWEEN 3.5 & 4.5; MELTS WITHIN A 3 DEG RANGE BETWEEN 135 DEG & 145 °C /CITRATE/

RECRYSTALLIZED FORM ETHYL ACETATE + ETHER; MP 151-153 °C /HCL/

CRYSTALS FROM ETHER /METHOBROMIDE/

NAUSEA, VOMITING, EPIGASTRIC DISTRESS, DIZZINESS, & PRURITUS HAVE BEEN OBSERVED.

...EFFECTS THAT MAY OCCUR AFTER THERAPEUTIC DOSES...INCL DIZZINESS, SWEATING, EUPHORIA, DRY MOUTH, NAUSEA, VOMITING, WEAKNESS, VISUAL DISTURBANCES, PALPITATION, DYSPHORIA, SYNCOPE & SEDATION. INCIDENCE & SEVERITY OF THESE RESPONSES ARE GREATER IN AMBULATORY PT THAN.../BED PT/. /MEPERIDINE/

OVERALL INCIDENCE OF INDIVIDUAL SIDE EFFECTS IS QUITE SIMILAR TO THAT OBSERVED AFTER EQUIANALGESIC DOSES OF MORPHINE, EXCEPT THAT CONSTIPATION & URINARY RETENTION DO NOT OCCUR AS FREQUENTLY AFTER MEPERIDINE. /MEPERIDINE/

IN ADDICTS TOLERANT TO DEPRESSANT EFFECTS OF MEPERIDINE, LARGE DOSES REPEATED @ SHORT INTERVALS PRODUCE TREMORS, MUSCLE TWITCHES, DILATED PUPILS, HYPERACTIVE REFLEXES, & CONVULSIONS. /MEPERIDINE/

For more Human Toxicity Excerpts (Complete) data for ETHOHEPTAZINE (7 total), please visit the HSDB record page.

PREPD IN SEVERAL STEPS FROM 2-PHENYL-4-DIMETHYLAMINOBUTYRONITRILE AS A STARTING MATERIAL, THE FINAL STEP BEING THE HYDROLYSIS & ESTERIFICATION OF 1-METHYL-4-PHENYL-4-CYANOAZACYCLOHEPTANE: DIAMOND ET AL, J ORG CHEM 22, 399 (1957); DIAMOND, BRUCE, US PATENT 2,666,050 (1954 TO AM HOME PROD).

AVAILABLE AS ETHOHEPTAZINE CITRATE IN 75 MG TABLETS. ALSO GENERALLY AVAILABLE IN MULTIPLE LAYERED TABLETS AS ZACTIRIN (CONTAINING 75 MG ETHOHEPTAZINE & 325 MG ASPIRIN), & ZACTIRIN COMPD-100 (CONTAINING 100 MG ETHOHEPTAZINE, 227 MG ASPIRIN, 162 MG PHENACETIN, & 32.4 MG CAFFEINE).