기본 정보
- 표준 SMILES
CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1.Cl- InChIKey
POUMFISTNHIPTI-BOMBIWCESA-N- 분자식
- C18H35ClN2O6S
- 평균 분자량
- 443 g/mol
- 단동위원소 질량
- 442.19043552
개요
Lincomycin Hydrochloride is the hydrochloride salt form of lincomycin, a lincosamide antibiotic originally identified in actinomycete Streptomyces lincolnensis with activity against gram-positive cocci and anaerobic bacteria.
이름 및 식별자
- 우선 이름
- Lincomycin Hydrochloride Anhydrous
- IUPAC
- (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide;hydrochloride
- 영어명
- Lincomycin hydrochloride
- 분자식
- C18H35ClN2O6S
- 분자량
- 443
이름 및 동의어
Lincomycin hydrochloride859-18-7LINCOMYCIN HCLLincomix 20Lincomycin hydrochloride anhydrousLincomixDTXSID7047803GCW8Y9936LLincomycin solubleLincolnensin hydrochlorideDTXCID9027780Lincomycin hydrochloride anhdrous
이름 더 보기
Lincomycin hydrochloride monohydrateLincomycin HCILincorexLintamycinMETHYL 6,8-DIDEOXY-6-(1-METHYL-4-PROPYL-2-PYRROLIDINECARBOXAMIDO)-1-THIO-D-ERYTHRO-ALPHA-D-GALACTOOCTOPYRANOSIDE HYDROCHLORIDE(2S,4R)-N-((1R,2R)-2-Hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochlorideLizpionU-10149ALincogap
D-erythro-alpha-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, monohydrochloride, (2S-trans)-NSC70731NSC-70731NSC-757092Linco SolubleLinxMed-SPLincomix 50LincoBac 300
데이터베이스 식별자
- CAS
859-18-7- PubChem CID
- 64710
- DTXSID
DTXSID7047803- ChEMBL
CHEMBL3989551- UNII
- GCW8Y9936L
- EC Number
- 212-726-7
물성
구조 계산 물성
- 극성 표면적
- 148 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 28
- 형식 전하
- 0
- 복잡도
- 498
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsActive Ingredients (Lincomycin Hydrochloride) -> FDA Greenbook
Collision Cross Section199.1 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 156 · 156-158C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 50 mg/mL, 투명, 무색
- 물리적 상태
- 고체
- 색상
- 흰색에서 노란색을 띠는 흰색
- 수용성
- 물에 용해됩니다.
- BRN
- 4171650 · 4171650
- 안정성
- 흡습성
- InChIKey
- POUMFISTNHIPTI-BOMBIWCESA-N
- SMILES
- [C@]([H])([C@]1([H])[C@@H]([C@H](O)[C@@H](O)[C@@H](SC)O1)O)([C@H](O)C)NC([C@H]1N(C[C@H](CCC)C1)C)=O.Cl |&1:0,2,4,5,7,9,14,19,22,r|
- EPA
- 6 · D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-, hydrochloride (1:1) (859-18-7)
화학적 성질
Crystalline
안전 및 규제
GHS 분류
GHS Classification
Warning
H315 (62.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 82 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Status: Active Update: 17-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/33514
lincomycin hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - D-erythro-.alpha.-D-galacto-Octopyranoside, methyl 6,8-dideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-, monohydrochloride, (2S-trans)-: Environment tier I assessment
Hazard Classes and CategoriesSkin Irrit. 2 (62.2%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Lincomycin hydrochloride
Ambiguous-DILI-concern
3
Warnings & precautions
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 2
- rtecs
- RH6315000
- HS 번호
- 29419000
- risk_code
- 36/37/38-20/21/22
- hazard_code
- Xi,Xn
- safety_code
- 26-36
- F 고인화성물질
- 10
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야
용도Lincomycin hydrochloride is a salt of lincomycin formed at the basic N-methylproline. The hydrochloride salt is the preferred formulation for pharmaceutical use. Lincomycin hydrochloride is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
일반 설명Chemical structure: macrolide
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