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Off-White to Pale Yellow Solid. Tylosin is a macrolide antibiotic which is active against certain Gram-positive and Gram-negative bacteria and Gram-positive mycoplasmas. It consists predominantly of tylosin(factor A), but varying amounts of desmycosin (factor B), macrocin (factor C) and relomycin(factor D) may also be present, depending on the manufacturing source. Most of themicrobiological activity resides with tylosin factor A. Tylosin is a weak organic base with a high degree of lipid solubility, thus it is well distributed to the organs and tissues of animals (Burrows, 1980). Tylosin is used in pigs, cattle and poultryfor the treatment of conditions caused by sensitive organisms. It may be administered by oral orparenteral routes. Tylosin is not used in human medicine.

개요Tylosin is a macrolide antibiotic produced by S. fradiae that has bacteriostatic activity against Gram-positive bacteria. It is a mixture of tylosin A, B, C, and D, with tylosin A contributing 80% of its bacteriostatic activity. Tylosin has MIC values of 9.6, 16.4, 0.1, 1, and 0.5 μg/ml for F. necrophorum, A. pyogenes, M. gallisepticum, S. aureus, and S. uberis, respectively.,, Formulations containing tylosin have been used for the prevention of liver abscesses in cattle. Tylosin is an environmental contaminant because it is not fully metabolized by treated livestock and enters the environment through manure-based fertilizers.

용도Tylosin is a 16-membered macrocyclic lactone isolated from Streptomyces fradiae in 1961. Tylosin has broad spectrum antibacterial activity and was developed as a veterinary pharmaceutical for treatment of bacterial infections in a range of domestic animals . Tylosin acts by binding to the 50S ribosomal subunit resulting in the inhibition of protein synthesis in bacteria.