기본 정보
- CAS
379-68-0- 표준 SMILES
C[C@]12CCC(=O)C=C1CC[C@H]1[C@@H]3CC[C@H](C(=O)CO)[C@@]3(CO)CC[C@@H]12- InChIKey
VPJHREHKRNIYDB-TZGXILGRSA-N- 분자식
- C21H30O4
- 평균 분자량
- 346.5 g/mol
- 단동위원소 질량
- 346.21440943
개요
18-hydroxydeoxycorticosterone is a 21-hydroxy steroid, a 18-hydroxy steroid, a 20-oxo steroid and a 3-oxo-Delta(4) steroid.
이름 및 식별자
- 우선 이름
- 18-Hydroxy-11-Deoxycorticosterone
- IUPAC
- (8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- 현지명
- 18-하이드록시-11-데옥시코르티코스테론
- 영어명
- 18-HYDROXY-11-DEOXYCORTICOSTERONE
- 분자식
- C21H30O4
- 분자량
- 346.46
이름 및 동의어
379-68-018-Hydroxy-11-deoxycorticosterone18-HydroxydeoxycorticosteroneDTXSID9095892018,21-dihydroxy-4-pregnene-3,20-dioneRefChem:388745DTXCID501386812206-834-318,21-Dihydroxypregn-4-ene-3,20-dione11-Deoxy-18-hydroxycorticosterone(8R,9S,10R,13R,14S,17S)-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-onePregn-4-ene-3,20-dione, 18,21-dihydroxy-
이름 더 보기
18-하이드록시-11-데옥시코르티코스테론18-HYDROXY DOC4-PREGNEN-18,21-DIOL-3,20-DIONE4-PREGNENE-18,21-DIOL-3,20-DIONE18,20-EPOXY-20,21-DIHYDROXY-4-PREGNEN-3-ONE
18,21-dihydroxyprogesterone18-Hydroxydesoxycorticosterone(1S,3aS,3bR,9aR,9bS,11aR)-1-(2-hydroxyacetyl)-11a-(hydroxymethyl)-9a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-oneEINECS 206-834-318-OH-DOCSCHEMBL927204orb2283106CHEBI:195166
물성
구조 계산 물성
- XLogP
- 1.5
- 극성 표면적
- 74.6 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 623
물리화학적 성질
- 녹는점
- 171 · 171-173 °C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 클로로포름(약간 용해됨, 초음파 처리), 메탄올(약간 용해됨, 가열)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- LogP
- 1.571 · 1.571 (est)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- safety_code
- 22-24/25
화학 및 산업
응용 분야
개요18-hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid secreted by the zona fasciculata of the adrenal gland. Its biosynthesis is regulated by adrenocorticotropic hormone (ACTH; ) as well as angiotensin II , which increases 18-OH-DOC production in isolated human adrenal glomerulosa cells. 18-OH-DOC can be formed via conversion of 11-deoxy corticosterone (DOC; ) in human SK-MEL188 melanoma cells. 18-OH-DOC is an intermediate in the metabolism of progesterone and can be converted to aldosterone by the capsular portion of rat adrenal glands. Continuous infusion of 18-OH-DOC (200 μg/rat per day) increases systolic blood pressure in uninephrectomized saline-drinking rats. Plasma levels of 18-OH-DOC are elevated in a db/db mouse model of type 2 diabetes.
용도11-Deoxy-18-hydroxycorticosterone is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.
공급사12 곳
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
上海维亦特生物科技有限公司15317051735 · [email protected]
BOC Sciences[email protected]
陕西缔都医药化工有限公司029-029-029-81148696 18161915376 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
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