기본 정보
- CAS
593-84-0- 표준 SMILES
N#CS.N=C(N)N- InChIKey
ZJYYHGLJYGJLLN-UHFFFAOYSA-N- 분자식
- CH5N3.CHNS
- 평균 분자량
- 118.16 g/mol
- 단동위원소 질량
- 118.03131738
개요
a powerful chaotropic agent
이름 및 식별자
- 우선 이름
- Guanidine thiocyanate
- IUPAC
- guanidine;thiocyanic acid
- 현지명
- 구아니딘 티오시안산염
- 영어명
- Guanidine thiocyanate
- 분자식
- CH5N3.CHNS
- 분자량
- 118.16
이름 및 동의어
Guanidine thiocyanate593-84-0Guanidinium thiocyanateGuanidine, monothiocyanateBUFFER AVLGCA2EU297UGuSCNNSC-2119DTXSID6060478RefChem:144652DTXCID1042601209-812-1
이름 더 보기
과니딘티오시아네이트구아니딘티오시안산염과니딘티오시아네이트(GUANIDINETHIOCYANATE)구아니딘 티오시이아네이트GUANIDINIUM ISOTHIOCYANATEGdmSCNabs9138usafek-705GUANIDIN THIOCYGTC,guanidineth
guanidine isothiocyanateguanidine;thiocyanic acidGuanidinium rhodanideMFCD00013027USAF EK-705M01833GTCguanidinethiocyanate
데이터베이스 식별자
- CAS
593-84-0- PubChem CID
- 65046
- DTXSID
DTXSID6060478- UNII
- GCA2EU297U
- EC Number
- 209-812-1
물성
구조 계산 물성
- 극성 표면적
- 101 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 7
- 형식 전하
- 0
- 복잡도
- 57.6
실험 및 물리화학적 성질
Chemical ClassesOther Uses -> Biochemical Research
Physical Description
Liquid; Dry Powder
White crystalline solid; Hygroscopic; [Sigma-Aldrich MSDS]
물리화학적 성질
- 녹는점
- 120 · 120-122 °C(lit.)
- 밀도
- 1.103 g/mL · 1.103 g/mL at 20 °C
- 증기압
- 0 Pa · 0Pa at 20℃
- 굴절률
- 20 · n20/D 1.482
- 저장 조건
- 20 · 20-25°C
- 용해도
- 2 O: · H2O: 6 M at 20 °C, 투명, 무색
- 물리적 상태
- 결정 또는 결정성 분말
- 산도 계수 (pKa)
- 12.5 · 12.5[at 20 ℃]
- 색상
- 흰색 또는 무색
- Specific Gravity
- 1.152 · 1.152
- 냄새
- 냄새 없는
- 수소이온지수(pH)
- 4.8 · 4.8-6.0 (1420g/l, H2O, 20℃)(saturated solution)
- 생물학적 소스
- synthetic (organic)
- 수용성
- 물과 에탄올에 용해됨
- BRN
- 3563461 · 3563461
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 0.2% (1 of 404) of reports.
Danger
H302+H312+H332 (45.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 404 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: Thiocyanic acid, compound with guanidine (1:1)
Thiocyanic acid, compd. with guanidine (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiocyanic acid, compd. with guanidine (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Guanidinium thiocyanate (EC: 209-812-1)
Guanidinium thiocyanate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryIntraperitoneal LD50 (mouse) = 300 mg/kg; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See Guanidine. See Sodium thiocyanate.
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
안전 및 보호
Protective Action Criteria (PAC)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
용도 및 제조
UsesA powerful chaotropic agent. [ChemIDplus] Used for RNA isolation and can solubilize proteins; [Santa Cruz Biotechnology]
U.S. Production2023: <50,000 lb
Consumer UsesLaboratory chemicals
Industry UsesLaboratory chemicals
General Manufacturing Information
Other (requires additional information)
Thiocyanic acid, compd. with guanidine (1:1): ACTIVE
응용 분야
용도Guanidine thiocyanate is a useful tool for RNA isolation and protein solubilization. It is involved in the quantification of mRNA from hepatocytes. It acts as a medium for blood smaple lystae in order to maintain the integrity of nucleic acid. It is a chaotropic agent, mainly involved in the extraction of DNA and RNA. It is utilized to deactivate the influenza virus.
일반 설명Guanidine thiocyanate is chaotropic salts which lyse cells and along with nuclease binding matrix it is also seen to inhibit nuclease activity during extraction of DNA. It works as a strong RNase inhibitor in extraction buffers.
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