기본 정보
- CAS
52212-02-9- 표준 SMILES
CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@H](N3CC[N+](C)(C)CC3)[C@@H]4OC(C)=O)[C@@]2(C)C[C@@H]1N1CC[N+](C)(C)CC1.[Br-].[Br-]- InChIKey
TXWBOBJCRVVBJF-YTGGZNJNSA-L- 분자식
- C35H62Br2N4O4
- 평균 분자량
- 762.7 g/mol
- 단동위원소 질량
- 760.31378
개요
Pipecuronium bromide is a steroid ester.
이름 및 식별자
- 우선 이름
- Pipecuronium Bromide
- IUPAC
- [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetyloxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate dibromide
- 영어명
- Pipecuronium bromide
- 분자식
- C35H62Br2N4O4
- 분자량
- 762.69918
이름 및 동의어
PIPECURONIUM BROMIDE52212-02-9Pipecurium bromideArduanPipecuronio bromuroRGH-1106RGH 1106Pipecuronium bromide anhydrousBromuro de pipecuronioBromure de pipecuroniumDTXSID8023478R6ZTY81RE1
이름 더 보기
PipecuroniumArdtmD00764Arduan (tn)Pipecuriurn BrmnidePIPECURINIUM BROMIDE
Pipecuronii bromidumBromide, PipecuriumBromide, PipecuroniumDTXCID403478RefChem:58792M03AC06RGH1106Pipecuronium (bromide)
데이터베이스 식별자
- CAS
52212-02-9- PubChem CID
- 65332
- DTXSID
DTXSID8023478- ChEMBL
CHEMBL1200722- ChEBI
CHEBI:8231- UNII
- R6ZTY81RE1
- EC Number
- 257-740-4
물성
구조 계산 물성
- 극성 표면적
- 59.1 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 45
- 형식 전하
- 0
- 복잡도
- 1,060
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 262 · 262-264° (dec)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO, 메탄올(약간), 물(약간) 에 용해됨
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- InChIKey
- TXWBOBJCRVVBJF-LQDGISGANA-L
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (94.4%): Fatal if swallowed [Danger Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P317, P321, P330, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 18 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 2 (94.4%)
안전 데이터
- 독성
- LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro)
화학 및 산업
약리 정보
ATC Code
M - Musculo-skeletal system
QM - Musculo-skeletal system
MeSH Pharmacological Classification
Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
응용 분야
용도Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery.
일반 설명Pipecurium bromide, 4,4 -(3 ,17 -dihydroxy-5 -androstan-2 ,16 -ylene)bis(1,1-dimeth-ylpiperazinium)dibromide diacetate (Arduan), is anondepolarizing muscle relaxant similar, both chemicallyand clinically, to pancuronium bromide. It is a long-actingdrug indicated as an adjunct to anesthesia and in patients undergoingmechanical ventilation.
상·하류 제품 정보
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