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기본 정보
- 표준 SMILES
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=CCS[C@H]12)c1csc(N)n1- InChIKey
NNULBSISHYWZJU-LLKWHZGFSA-N- 분자식
- C13H13N5O5S2
- 평균 분자량
- 383.411 g/mol
- 단동위원소 질량
- 383.03581052
이름 및 식별자
- 우선 이름
- Ceftizoxime
- IUPAC
- (6R,7R)-7-{[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- 영어명
- Ceftizoxime
- 분자식
- C13H13N5O5S2
- 분자량
- 383.4
이름 및 동의어
(6R,7R)-7-[(Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetylamino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acidCefimxCeftizoxEPOCELINFR-13749CeftisominCEFTIZOXIMECeftizoxime >CEFTIZOXIME ACIDCeftizoxime (350 mg)
데이터베이스 식별자
- CAS
68401-81-0- PubChem CID
- 6533629
- DTXSID
DTXSID5022772- ChEMBL
CHEMBL528- ChEBI
CHEBI:553473- UNII
- C43C467DPE
- EC Number
- 685-309-4
- Nikkaji
- J37.178E
물성
물리화학적 성질
- 녹는점
- 227 ° · 227° (dec)
- 밀도
- 1.89 · 1.89±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · under inert gas (nitrogen or Argon) at 2–8 °C
- 용해도
- Aqueous Base (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 2.1 · pKa 2.1 (Uncertain)
- 색상
- 흰색에서 연한 노란색
- Merck
- 14 · 14,1951
- 안정성
- 흡습성
- InChIKey
- NNULBSISHYWZJU-LLKWHZGFSA-N
- SMILES
- N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC=C2C(O)=O
안전 및 규제
안전 데이터
- rtecs
- XI0367375
- 독성
- LD50 intravenous in rat: 8gm/kg
- HS 번호
- 2941906000
화학 및 산업
응용 분야
개요In ceftizoxime, the whole C-3 side chain has been omitted to prevent deactivation by hydrolysis. It rather resembles cefotaxime in its properties; however, not being subject to metabolism, its pharmacokinetic properties are much less complex.
용도Ceftizoxime is used for bacterial infections of the lower respiratory tract, infections of the urinary tract, infections of the bones, joints, skin, soft tissues, and abdominal infections. Synonyms of this drug are ceftix and eposerin.
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추가 설명
정의ChEBI: A parenteral third-generation cephalosporin, bearing a 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino group at the 7beta-position.
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