도파민 하이드로클로라이드
Dopamine Hydrochloride
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기본 정보
- CAS
62-31-7- 표준 SMILES
Cl.NCCc1ccc(O)c(O)c1- InChIKey
CTENFNNZBMHDDG-UHFFFAOYSA-N- 분자식
- C8H12ClNO2
- 평균 분자량
- 189.64 g/mol
- 단동위원소 질량
- 189.0556563
개요
Dopamine hydrochloride is a catecholamine.
이름 및 식별자
- 우선 이름
- Dopamine Hydrochloride
- IUPAC
- 4-(2-aminoethyl)benzene-1,2-diol;hydrochloride
- 현지명
- 도파민 하이드로클로라이드
- 영어명
- Dopamine hydrochloride
- 분자식
- C8H12ClNO2
- 분자량
- 189.64
이름 및 동의어
Dopamine hydrochloride62-31-7Dopamine HClCardiosterilInotropin1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochlorideTensamin4-(2-Aminoethyl)pyrocatechol hydrochlorideASL-279DTXSID7020550NSC-169105Dopamini hydrochloridum
이름 더 보기
도파민수화염화물도파민하이드로클로라이드도파민수화염화물3-HYDROXYTYRAMINE HYDROCHLORIDE2-benzenediol,4-(2-aminoethyl)-hydrochloride2-(3,4-DIHYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDEintropinDopamin HclDopamine HCIdopaminechloride
7L3E358N9LDopamine hydrochloride in dextrose 5%Dopamine hydrochloride and dextrose 5%DTXCID50550Dopamine hydrochloride in dextrose 5% in plastic containerDopamine hydrochloride and dextrose 5% in plastic containerNSC173182Dopaminergic
데이터베이스 식별자
- CAS
62-31-7- PubChem CID
- 65340
- DTXSID
DTXSID7020550- ChEMBL
CHEMBL1557- ChEBI
CHEBI:4698- UNII
- 7L3E358N9L
- EC Number
- 200-527-8
물성
구조 계산 물성보충 중
- 극성 표면적
- 66.5 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 119
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 248 · 248-250 °C(lit.)
- 밀도
- 1.4 g/cm3 · 1.4 g/cm3
- 인화점
- 11 ℃ · 11℃
- 저장 조건
- 30 °C · Store below +30°C.
- 용해도
- 20 mg/mL · 알코올: 20mg/mL
- 물리적 상태
- 결정성 분말
- 색상
- 베이지색
- 수용성
- 녹는
- Merck
- 14 · 14,8462
- BRN
- 3656720 · 3656720
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다. 타기 쉬운.
- 주요 응용
- 의약품(소분자)
- InChI
- 1S/C8H11NO2.ClH/c9-4-3-6-1-2-7(10)8(11)5-6;/h1-2,5,10-11H,3-4,9H2;1H
- InChIKey
- CTENFNNZBMHDDG-UHFFFAOYSA-N
- SMILES
- Cl[H].NCCc1ccc(O)c(O)c1
- EPA
- 1 · 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (62-31-7)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (84.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P273, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 51 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationDopamine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (84.3%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Dopamine hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- UX1092000
- ridadr
- UN1230 - class 3 - PG 2 - Methanol, solution
- 독성
- LD50 orally in Rabbit: 2859 mg/kg
- HS 번호
- 29222900
화학 및 산업
약리 정보
FDA Pharmacological Classification
DOPAMINE HCI
Catecholamines [CS]; Catecholamine [EPC]
DOPAMINE HCI IN 5% DEXTROSE
Catecholamines [CS]; Catecholamine [EPC]
DOPAMINE HYDROCHLORIDE
Catecholamines [CS]; Catecholamine [EPC]
MeSH Pharmacological Classification
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
용도 및 제조
UsesUse (kg; approx.) in Germany (2009): >25
General Manufacturing Information1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (1:1): ACTIVE
응용 분야
용도면역 기능 약제, 도파민 HCL.
개요Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5). Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes. Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.
관련 반응
70건
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