기본 정보
- CAS
61477-94-9- 표준 SMILES
C[C@@H]1CCC[C@H](C)N1CCCC(O)(c1ccccc1)c1ccccn1.Cl- InChIKey
HFIHPVIVQSWZBV-ROSXHPEZSA-N- 분자식
- C22H31ClN2O
- 평균 분자량
- 374.9 g/mol
- 단동위원소 질량
- 374.2124913
개요
See also: Pirmenol (has active moiety).
이름 및 식별자
- 우선 이름
- Pirmenol Hydrochloride
- IUPAC
- 4-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol;hydrochloride
- 영어명
- Pirmenol hydrochloride
- 분자식
- C22H31ClN2O
- 분자량
- 374.95
이름 및 동의어
pirmenol hydrochloride61477-94-9PirmavarPirmenol HClDTXSID6021169CI-845CL-845Pirmenol monohydrochlorideCL-845 HYDROCHLORIDERefChem:929351DTXCID701169JA79OMG4QT
이름 더 보기
PimavarCcris 5234(à)-Pirmenol hydrochloridPirmenol hydrochloride(cis)Pirmenol hydrochloride, >97%
Pirmenol (hydrochloride)Pirmenol.HCl4-((2R,6S)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol hydrochlorideCI 845Cl 8454-[(2R,6S)-2,6-dimethylpiperidin-1-yl]-1-phenyl-1-pyridin-2-ylbutan-1-ol;hydrochloride4-[(2R,6S)-2,6-dimethyl-1-piperidyl]-1-phenyl-1-pyridin-2-yl-butan-1-o l hydrochloriderel-4-((2R,6S)-2,6-Dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol hydrochloride
데이터베이스 식별자
- CAS
61477-94-9- PubChem CID
- 65501
- DTXSID
DTXSID6021169- ChEMBL
CHEMBL1204211
물성
구조 계산 물성
- 극성 표면적
- 36.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 385
물리화학적 성질
- 녹는점
- 171 · 171-172 °C
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 28 mg/mL · DMSO : ≥ 28 mg/mL (74.68 mM)
- 물리적 상태
- Solid
- 색상
- White to yellow
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
응용 분야
개요Pirrnenol hydrochloride is a long-lasting Class la antiarrhythmic agent introduced in Japan in 1994. The spectrum of antiarrhythmic activity of pirmenol includes atrial and ventricular arrhythmias of diverse etiology. In clinical trials, pirmenol was found effective in the short- and mid-term treatment of chronic premature ventricular beats, with or without underlying heart disease. In patients with supraventricular tachycardia, a single oral dose of pirmenol was highly effective in suppressing induction of tachycardia with adequate hemodynamic tolerance. Since pirmenol is highly effective by both intravenous and oral routes, it enables immediate suppression, prevention, or termination of cardiac arrhythmias and facilitates the transition to oral prophylactic therapy.
용도Cardiac depressant (anti-arrhythmic).
공급사24 곳
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海冬洋生物科技有限公司0512-13601744364 13601744364 · [email protected]
Hunan Jibang Biological Technology Co., LTD13776644403 · [email protected]
InvivoChem中国13549236410 · [email protected]
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