기본 정보
- CAS
63516-07-4- 표준 SMILES
C[N+]1(CCF)[C@@H]2CC[C@H]1CC(OC(=O)C(O)(c1ccccc1)c1ccccc1)C2.[Br-]- InChIKey
FNUZASGZEHGWQM-RJRMRWARSA-M- 분자식
- C24H29BrFNO3
- 평균 분자량
- 478.4 g/mol
- 단동위원소 질량
- 477.13148
개요
Flutropium bromide is the organic bromide salt of flutropium. It is used in Japan for the treatment asthma and chronic obstructive pulmonary disease. It has a role as a muscarinic antagonist, an anti-asthmatic drug and an antispasmodic drug. It contains a flutropium.
이름 및 식별자
- 우선 이름
- Flutropium bromide
- IUPAC
- [(1S,5R)-8-(2-fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide
- 영어명
- Flutropium bromide
- 분자식
- C24H29FNO3.Br
- 분자량
- 478.39
이름 및 동의어
flutropium bromide63516-07-4Bronchospasmolytic agent 1Bromuro de flutropioBromure de flutropiumFlutropii bromidumFlutropium (bromide)Ba 598 BRDTXSID304865563516-10-9K3V6HB0M57DTXCID5032365
이름 더 보기
Ba 598FlubronBa 598BrFlutropiumFlutropiumbromidFlutropium bromide USP/EP/BPTIANFU-CHEM_Flutropium Bromide Hydrate 63516-07-4[8-(2-Fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate bromide(1R,5S,8-syn)-8-Methyl-8-(2-fluoroethyl)-3α-[[diphenyl(hydroxy)acetyl]oxy]-8-azoniabicyclo[3.2.1]octane
FLUTROPIUM BROMIDE [JAN]Ba 598Br; Flubron[(1S,5R)-8-(2-fluoroethyl)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2,2-diphenylacetate;bromideCAS-63516-07-4Flutropii bromidum [Latin]UNII-K3V6HB0M57Flutropium bromide [INN:JAN]Bromure de flutropium [French]
데이터베이스 식별자
- CAS
63516-07-4- PubChem CID
- 656602
- DTXSID
DTXSID3048655- ChEMBL
CHEMBL2104729- ChEBI
CHEBI:31630- UNII
- K3V6HB0M57
물성
구조 계산 물성
- 극성 표면적
- 46.5 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 538
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Respiratory system -> Nasal preparations
물리화학적 성질
- 녹는점
- 192 · 192-193° (dec); mp 198-199° (dec)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 독성
- LD50 in male, female mice, male, female rats (mg/kg): 12.5, 11.0, 16.4, 18.4 i.v.; 760, 810, 830, 740 orally (Bauer, Fügner)
화학 및 산업
응용 분야
개요Flutropium bromide is an antitussive useful in the treatment of allergic rhinitis and in the symptomatic relief of bronchial asthma and chronic bronchitis. Recent studies suggest that flutropium bromide may have potential as a long-acting alternative to P-sympathomimetics or the xanthines in the prophylaxis of obstructive airways disease.
상·하류 제품 정보
상류 원료
공급사19 곳
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Protheragen-ING+86-15618352007 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
武汉鹏胤药业有限公司13163333255 · [email protected]
上海拓目化工有限公司13391076197 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
北京禾兴源科技有限公司18511709189 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
Shaanxi Dideu New Materials Co. Ltd18192503167 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
河南天孚化工有限公司+86-0371-55170693 +86-19937530512 · [email protected]
湖北康鑫源顺医药化工有限公司027-51831887 15337167856 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
济南光尘医药科技有限公司18563726319 · [email protected]
重庆卡兰医药有限公司[email protected]
HANGZHOU CLAP TECHNOLOGY CO.,LTD86-571-88216897,88216896 13588875226 · [email protected]
Hefei TNJ Chemical Industry Co.,Ltd.+86-0551-65418671 +86-189 4982 3763 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]
Dideu Industries Group Limited+8617392712697 · [email protected]
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