기본 정보
- CAS
21730-16-5- 표준 SMILES
CNC1Cc2ccccc2N(C)c2ccccc21- InChIKey
YXVZOBVWVRFPTE-UHFFFAOYSA-N- 분자식
- C16H18N2
- 평균 분자량
- 238.33 g/mol
- 단동위원소 질량
- 238.14699858
개요
Metapramine is a dibenzooxazepine.
이름 및 식별자
- 우선 이름
- Metapramine
- IUPAC
- N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine
- 영어명
- Metapramine
- 분자식
- C16H18N2
- 분자량
- 238.33
이름 및 동의어
Metapramine21730-16-5MetapraminaMetapraminum303954M7YF10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz(b,f)azepineDTXSID6086501119560-RPRefChem:156796DTXCID7081346715-methyl-10-methylamino-10,11-dihydrodibenzo(b,f)-azepineMetapramine [INN]
이름 더 보기
RP 19560Metapramine USP/EP/BP10,11-Dihydro-5-Methyl-10-5H-Dibenz[b,f]azepine5-Methyl-10-MethylaMino-10,11-dihydrodibenzo[b,f]azepine10,11-Dihydro-N,5-diMethyl-5H-Dibenz[b,f]azepin-10-aMine5H-Dibenz[b,f]azepin-10-amine, 10,11-dihydro-N,5-dimethyl-10,11-Dihydro-5-methyl-10-(methylamino)-5H-dibenz[b,f]azepine
N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amineMetapraminum [Latin]Metapramina [Spanish]Metapraminum [INN-Latin]Metapramina [INN-Spanish]10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-methyl-10-(methylamino)- (8CI); 10,11-Dihydro-N,5-dimethyl-5H-dibenz[b,f]azepin-10-amine; 5-Methyl-10-methylamino-10,11-dihydrodibenzo[b,f]azepine; Metapramine; RP 1956019560 RPMETAPRAMINE [MI]
데이터베이스 식별자
- CAS
21730-16-5- PubChem CID
- 65700
- DTXSID
DTXSID60865011- ChEMBL
CHEMBL2106919- ChEBI
CHEBI:134971- UNII
- 303954M7YF
- Nikkaji
- J11.156B
물성
구조 계산 물성
- XLogP
- 3
- 극성 표면적
- 15.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 18
- 형식 전하
- 0
- 복잡도
- 278
물리화학적 성질
- 녹는점
- 237 · 237-240 °C
- 끓는 점
- 350.8 · 350.8±42.0 °C(Predicted)
- 밀도
- 1.12 · 1.12±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 기름
- 산도 계수 (pKa)
- 9.09 · 9.09±0.20(Predicted)
- 색상
- 무색~담황색
- 안정성
- 흡습성
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However, the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
응용 분야
개요Metapramine is an antidepressant with a pharmacological profile similar to the tricyclics and an apparent rapid clinical onset of action. Metapramine differs biochemically from the tricyclics in that it markedly enhances norepinephrine turnover with minimal inhibition of reuptake. Like the tricyclics, however, it does down regulate β-receptors.
용도Metapramine is a tricyclic antidepressant derived from dibenzoazepine. Metapramine acts as a norepinephrine reuptake inhibitor without affecting the reuptake of serotonin or dopamine.
상·하류 제품 정보
상류 원료
공급사13 곳
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