Thioridazine hydrochloride
THIORIDAZINE HCL · L-714 · Ridazin · Orsanil · usafsz-3 · USAF SZ-B · Stalleril · NSC 186060
식별자 및 물리적 특성
| CAS No. | 130-61-0 |
|---|---|
| 분자식 | C21H27ClN2S2 |
| 평균 분자량 | 407.04 g/mol |
| SMILES | CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2.[Cl-].[H+] |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| PubChem CID | 657213 |
화학 및 물리적 성질
| 녹는점 | 158-1600C |
|---|---|
| 끓는 점 | 230°C (rough estimate) |
| 밀도 | 1.1227 (rough estimate) |
| 굴절률 | 1.5610 (estimate) |
| 저장 조건 | 2-8°C |
| 용해도 | H2O: 가용성 250 mg + 용매 5 ml, 투명, 무색 내지 희미한 노란색 |
| 물리적 상태 | 회백색 고체 |
| 색상 | 흰색에서 거의 흰색 |
| 용해도 | 물(75mM), DMSO(100mM), 클로로포름, 에탄올 및 메탄올에 용해됩니다. |
| Merck | 14,9359 |
| InChI | 1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3 |
| InChIKey | NZFNXWQNBYZDAQ-UHFFFAOYSA-N |
| SMILES | Cl.CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 |
| NIST | Thioridazine hydrochloride(130-61-0) |
| EPA | 10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylthio)-, monohydrochloride (130-61-0) |
화학적 성질
Pale Yellow Solid
안전 및 규제
| 수질 위해 등급(WGK) | 3 |
|---|---|
| RTECS 번호 | SP2275000 |
| 운송 번호(UN) | UN 3077 9/PG 3 |
| 관세 코드 | 2934302300 |
| 위험 문구(R) | 22-36/37/38-50/53 |
| 위험 표시 | Xn,N |
| 안전 문구(S) | 26-36-60-61 |
| 위험 등급 | 9Acute Tox. 4 Oral |
| 기존화학 물질 | KE-24858 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes.
일반 설명
Thioridazine hydrochloride,10-[2-(1-methyl-2-piperidyl)ethyl]-2-(methylthio)phenothiazine monohydrochloride (Mellaril), is amember of the piperidine subgroup of the phenothiazines.The drug has a relatively low tendency to produce EPS. Thedrug has high anticholinergic activity, and this activity in thestriatum, counterbalancing a striatal DA block, may be responsiblefor the low EPS. It also has been suggested thatthere may be increased DA receptor selectivity, which may be responsible. The drug has sedative and hypotensive activityin common with chlorpromazine and less antiemeticactivity. At high doses, pigmentary retinopathy has been observed.Its major metabolites include N-demethylated, ringhydroxylated,and S-oxidized products. Thioridazine isprominently converted to the active metabolite mesoridazine(discussed next), which probably contributes to the antipsychoticactivity of thioridazine.