기본 정보
- CAS
28319-77-9- 표준 SMILES
C[N+](C)(C)CCOP(=O)([O-])OC[C@H](O)CO- InChIKey
SUHOQUVVVLNYQR-MRVPVSSYSA-N- 분자식
- C8H20NO6P
- 평균 분자량
- 257.22 g/mol
- 단동위원소 질량
- 257.10282399
개요
Choline alfoscerate is a member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. It has a role as a parasympatholytic, a neuroprotective agent, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a human metabolite. It is a member of sn-glycerol 3-phosphates and a member of phosphocholines.
이름 및 식별자
- 우선 이름
- Choline Alfoscerate
- IUPAC
- [(2R)-2,3-dihydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
- 현지명
- 글리세로포스포콜린
- 영어명
- Choline glycerophosphate
- 분자식
- C8H20NO6P
- 분자량
- 257.22
이름 및 동의어
Choline AlfoscerateSN-glycero-3-phosphocholine28319-77-9Choline glycerophosphateL-alpha-GlycerophosphorylcholineGlycerophosphorylcholineL-alpha-GlycerophosphocholineCholine AlphoscerateGPChoCholini glycerophosphasCholini alfoscerasGlicerofosfato de colina
이름 더 보기
글리세로포스포콜린Alpha GPCGPCglycerophosphocholineL-ALPHA-GLYCERYLPHOSPHORYLCHOLINEAlpha GPC powderL-α-glycerylphosphorylcholineQuaternary ammonium salt
alpha-GlycerophosphorylcholineAlfoscerato de colinaGlycerophosphate de cholineAlfoscerate de cholinealpha-GlycerylphosphorylcholineGlycerol phosphorylcholineSn-3-GPCglycerol-3-phosphocholine
데이터베이스 식별자
- CAS
28319-77-9- PubChem CID
- 657272
- DTXSID
DTXSID70951010
물성
구조 계산 물성
- XLogP
- -2.3
- 극성 표면적
- 99.1 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 233
실험 및 물리화학적 성질
Melting Point142.5 °C
Physical DescriptionSolid
Collision Cross Section
155.5 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
157.17 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
물리화학적 성질
- 녹는점
- 142.5 · 142.5-143°
- 끓는 점
- 480 ℃[at · 480℃[at 101 325 Pa]
- 증기압
- 0 Pa · 0Pa at 25℃
- 인화점
- 11 °C · 11 °C
- 저장 조건
- -20 °C · -20°C
- 용해도
- DMSO(약간 가열, 초음파 처리), 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- 생물학적 소스
- soybean
- 수용성
- 1000 g/L · 1000g/L at 25℃
- 안정성
- 흡습성이 매우 높음
- 화장품 원료 기능
- 피부 컨디셔닝
- InChI
- InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (6 of 6) of all reports.
Not Classified
Aggregated GHS information provided per 6 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory InformationStatus: Active Update: 13-12-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25611
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- 2
- rtecs
- KH2775000
- ridadr
- UN 1230 3/PG 2
- HS 번호
- 29239000
- risk_code
- 11-23/24/25-39/23/24/25
- hazard_code
- F,T
- safety_code
- 16-36/37-45-24/25
- 기존화학 물질
- KE-05955
화학 및 산업
약리 정보
ATC Code
N - Nervous system
QN - Nervous system
Tissue LocationsBrain
Cellular LocationsCytoplasm
Metabolite PathwaysRetinol Metabolism
응용 분야
개요Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated memory impairment. In man, it decreased and prevented scopolamine-induced amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic transmission by elevating the synthesis of acetylcholine.
용도sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic.
일반 설명L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine.
상·하류 제품 정보
상류 원료
관련 반응
2건
화합물 노트
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