기본 정보
- CAS
38129-37-2- 표준 SMILES
C=C1CCO[C@]2([C@@H](O)[C@@](C)(O)CO)NC(=O)[C@@]1(O)NC2=O- InChIKey
WOUDXEYYJPOSNE-VKZDFBPFSA-N- 분자식
- C12H18N2O7
- 평균 분자량
- 302.28 g/mol
- 단동위원소 질량
- 302.11140092
개요
Bicozamycin is a commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli. It has a role as an antibacterial agent, an antiinfective agent and an antidiarrhoeal drug. It is a bridged compound and an azabicycloalkane.
이름 및 식별자
- 우선 이름
- Bicyclomycin
- IUPAC
- (1S,6R)-6-hydroxy-5-methylidene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione
- 현지명
- 비코자마이신
- 영어명
- bicozamycin
- 분자식
- C12H18N2O7
- 분자량
- 302.28
이름 및 동의어
BicyclomycinBicozamycinAizumycin38129-37-2BicozamicinaBicozamycineAntibiotic 5879BicozamycinumWS-4545 ANTIBIOTIC(1S,6R)-6-hydroxy-5-methylidene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-2-oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dioneJ03U9E2P82CGP-3543
이름 더 보기
비코자마이신C11259WS-4545ICOZAMYCINBicozaMycin benzoateBicozaMycin, AizuMycin, Bacteron, CGP 3543E, WS4545, 5879(1R,6S)-1-hydroxy-2-methylidene-6-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-5-oxa-8,10-diazabicyclo[4.2.2]decane-7,9-dione2-Oxa-7,9-diazabicyclo[4.2.2]decane-8,10-dione, 6-hydroxy-5-methylene-1-[(1S,2S)-1,2,3-trihydroxy-2-methylpropyl]-, (1S,6R)-
NSC-180516CHEBI:60584DTXSID8042636(1S,6R)-6-hydroxy-5-methylidene-1-((1S,2S)-1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo(4.2.2)decane-8,10-dioneRefChem:119658DTXCID6022636(1S,6R)-6-hydroxy-5-methylidene-1-((1R,2S)-1,2,3-trihydroxy-2-methylpropyl)-2-oxa-7,9-diazabicyclo(4.2.2)decane-8,10-dione253-795-3
물성
구조 계산 물성
- XLogP
- -2.9
- 극성 표면적
- 148 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 510
물리화학적 성질
- 녹는점
- 188 · 188-191° (dec); mp 187-189° (dec) (Imanaka); mp 166-170° (Nakatsuka et al.)
- 끓는 점
- 786.6 · 786.6±60.0 °C(Predicted)
- 밀도
- 1.57 · 1.57±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- 9.85 · 9.85±0.60(Predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 1 (100%)
안전 데이터
- 독성
- LD50 in mice: >4 g/kg (Williams, Durham)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Substances that inhibit the growth or reproduction of BACTERIA.
응용 분야
용도Bicyclomycin is a polar metabolite first isolated from Streptomyces sapporonensis in 1972. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites. The primary site of action for bicyclomycin is thought to be the rho transcription termination factor.
공급사17 곳
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
上海赛可锐生物科技有限公司021-58000709 13120558703 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
孟成科技（上海）有限公司400-820-6829 · [email protected]
上海维亦特生物科技有限公司15317051735 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
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