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기본 정보
- CAS
38321-02-7- 표준 SMILES
COc1ccc(CCN(C)CCC[C@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC- InChIKey
SGTNSNPWRIOYBX-HHHXNRCGSA-N- 분자식
- C27H38N2O4
- 평균 분자량
- 454.611 g/mol
- 단동위원소 질량
- 454.2831577
이름 및 식별자
- 우선 이름
- Dexverapamil
- IUPAC
- (2R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
- 영어명
- (+)-3-(3,4-dimethoxyphenyl)-6-[(5,6-dimethoxyphenethyl)methylamino]hexane-3-carbonitrile
- 분자식
- C27H38N2O4
- 분자량
- 454.61
이름 및 동의어
d-VerapamilDexverapamiDexverapamilDexverapamil Hydrochloride[R,(+)]-2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(N-methyl-3,4-dimethoxyphenethylamino)valeronitrile(R)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrile(aR)-a-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-benzeneacetonitrile(αR)-α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)benzeneacetonitrileBenzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-, (R)-Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-, (αR)-
데이터베이스 식별자
- CAS
38321-02-7- PubChem CID
- 65808
- DTXSID
DTXSID501009404- ChEMBL
CHEMBL197- ChEBI
CHEBI:77734- UNII
- QR5PYD126V
- EC Number
- 253-878-4
- Nikkaji
- J221.681G
물성
물리화학적 성질
- 녹는점
- 129 · 129-131°C
- 끓는 점
- 586.1 · 586.1±50.0 °C(Predicted)
- 밀도
- 1.058 · 1.058±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 8.97 · 8.97±0.50(Predicted)
화학적 성질
Off-White Solid
화학 및 산업
응용 분야
용도Both isomers inhibit the p-glycoprotein efflux pump in multidrug resistant tumor cells
공급사10 곳
湖北瑞玛标物科技有限公司15787879035 15787875101 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Clearsynth Labs Limited+91-22-26355700 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
DAYANG CHEM (HANGZHOU) CO.,LTD+86-88938639 +86-17705817739 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
广州奥司汀生物技术有限公司15918640830 13268843209 · [email protected]
广州优南科技有限公司020-82000279 18988941452 · [email protected]
추가 설명
정의ChEBI: A 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile that has R configuration. It competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1, EC 3.6.3.44), thereby p tentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms. Dexverapamil exhibits lower calcium antagonistic activity and toxicity than racemic verapamil.
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