프로카인아미드하이드로클로라이드
Procainamide Hydrochloride
기본 정보
- CAS
614-39-1- 표준 SMILES
CCN(CC)CCNC(=O)c1ccc(N)cc1.Cl- InChIKey
ABTXGJFUQRCPNH-UHFFFAOYSA-N- 분자식
- C13H22ClN3O
- 평균 분자량
- 271.78 g/mol
- 단동위원소 질량
- 271.14514
개요
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.
이름 및 식별자
- 우선 이름
- Procainamide Hydrochloride
- IUPAC
- 4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride
- 현지명
- 프로카인아미드하이드로클로라이드
- 영어명
- Procainamide hydrochloride
- 분자식
- C13H22ClN3O
- 분자량
- 271.79
이름 및 동의어
procainamide hydrochloride614-39-1Procainamide HclProcanbidProcapanProcan SRPronestyl-SrAmidoprocaineCardiorytminBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochlorideNovocamid hydrochlorideDTXSID2049422
이름 더 보기
프로카인아미드하이드로클로라이드프로카인아미드하이드로클로라이드벤자마이드,4-아미노-N-(2-(다이에틸아미노)에틸)-,하이드로클로라이드(1:1)PronestylPromideAmisalinamidoprocainTIMTEC-BB SBB001067promidehydrochlorideProcainaMide HCl USP
NSC-757279SI4064O0LXProcainamidi hydrochloridumBenzamide, 4-amino-N-(2-(diethylamino)ethyl)-, monohydrochlorideCHEBI:8429DTXCID10293824-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride
데이터베이스 식별자
- CAS
물성
구조 계산 물성
- 극성 표면적
- 58.4 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 18
- 형식 전하
- 0
- 복잡도
- 221
실험 및 물리화학적 성질
Solubility>40.8 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section155.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 165 · 165-168 °C
- 밀도
- 1.2027 · 1.2027 (rough estimate)
- 굴절률
- 1.633 · 1.6330 (estimate)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 가용성 1g/10mL, 투명하고 녹황색
- 물리적 상태
- 가루
- 색상
- 흰색에서 약간 노란색
- 수용성
- 녹는
- Merck
- 13 · 13,7845
- BRN
- 3729517 · 3729517
- InChI
- InChI=1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H
- InChIKey
- ABTXGJFUQRCPNH-UHFFFAOYSA-N
- SMILES
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 47 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Other Safety InformationIMAP assessments - Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Procainamide hydrochloride
vLess-DILI-concern
4
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- CV2295000
- HS 번호
- 29242990
- risk_code
- 22-36/37/38
- hazard_code
- Xn
- safety_code
- 26-36-37/39
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
화학 및 산업
약리 정보
FDA Pharmacological Classification
PROCAINAMIDE HCI
Antiarrhythmic [EPC]
PROCAINAMIDE HYDROCHLORIDE
Antiarrhythmic [EPC]
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
용도 및 제조
General Manufacturing InformationBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1): ACTIVE
응용 분야
용도Procainamide hydrochloride (PAH) is suitable to investigate its binding behavior with human serum albumin and bovine serum albumin by fluorescence quenching study to understand the pharmacokinetic and pharmacodynamic mechanisms of PAH.
일반 설명Procainamide hydrochloride,p-amino-N-[2-(diethylamino)ethyl]benzamidemonohydrochloride, procainamidium chloride (Pronestyl,Procan SR), has emerged as a major antiarrhythmic drug. Itwas developed in the course of research for compoundsstructurally similar to procaine, which had limited effectas an antiarrhythmic agent because of its central nervoussystem (CNS) side effects and short-lived action causedby rapid hydrolysis of its ester linkage by plasma esterases.Because of its amide structure, procainamide hydrochlorideis also more stable in water than is procaine. Aqueoussolutions of procainamide hydrochloride have a pH ofabout 5.5. A kinetic study of the acid-catalyzed hydrolysisof procainamide hydrochloride showed it to be unusuallystable to hydrolysis in the pH range 2 to 7, even at elevatedtemperatures.
관련 반응
4건
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