기본 정보
- 표준 SMILES
CCN(CC)CCNC(=O)c1ccc(N)cc1.Cl- InChIKey
ABTXGJFUQRCPNH-UHFFFAOYSA-N- 분자식
- C13H22ClN3O
- 평균 분자량
- 271.78 g/mol
- 단동위원소 질량
- 271.14514
개요
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.
이름 및 식별자
- 우선 이름
- Procainamide Hydrochloride
- IUPAC
- 4-amino-N-[2-(diethylamino)ethyl]benzamide;hydrochloride
이름 및 동의어
procainamide hydrochloride614-39-1Procainamide HclProcanbidProcapanProcan SRPronestyl-SrAmidoprocaineCardiorytminBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochlorideNovocamid hydrochlorideDTXSID2049422
이름 더 보기
NSC-757279SI4064O0LXProcainamidi hydrochloridumBenzamide, 4-amino-N-(2-(diethylamino)ethyl)-, monohydrochlorideCHEBI:8429DTXCID10293824-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride
데이터베이스 식별자
- CAS
614-39-1- PubChem CID
- 66068
- DTXSID
DTXSID2049422- ChEMBL
CHEMBL605- UNII
- SI4064O0LX
- EC Number
- 210-381-7
물성
구조 계산 물성
- 극성 표면적
- 58.4 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 18
- 형식 전하
- 0
- 복잡도
- 221
실험 및 물리화학적 성질
Solubility>40.8 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section155.8 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
안전 및 규제
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 47 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Other Safety InformationIMAP assessments - Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Procainamide hydrochloride
vLess-DILI-concern
4
Adverse reactions
DOI:10.1016/j.drudis.2016.02.015
화학 및 산업
약리 정보
FDA Pharmacological Classification
PROCAINAMIDE HCI
Antiarrhythmic [EPC]
PROCAINAMIDE HYDROCHLORIDE
Antiarrhythmic [EPC]
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.
용도 및 제조
General Manufacturing InformationBenzamide, 4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1): ACTIVE
관련 반응
4건
연결된 노트
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