기본 정보
- 표준 SMILES
Cc1cccc(Cn2nc(C3CC3)c3c(NC(=O)c4cnc5cc(OCCN6CCN(C)CC6)ccn45)cccc32)n1- InChIKey
JUPOTOIJLKDAPF-UHFFFAOYSA-N- 분자식
- C32H36N8O2
- 평균 분자량
- 564.7 g/mol
개요
cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.
이름 및 식별자
- 우선 이름
- Arry-382
- IUPAC
- N-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
이름 및 동의어
ARRY-382c-Fms-IN-12ARRY382ARRY 382N-[3-cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamidePF-07265804PF07265804N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo(1,2-a)pyridine-3-carboxamideRefChem:114168cFMS Tyrosine Kinase Inhibitor ARRY-3821313407-95-2N-(3-cyclopropyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)imidazo[1,2-a]pyridine-3-carboxamide
이름 더 보기
N-[3-Cyclopropyl-1-[(6-methylpyridin-2-yl)methyl]-1H-indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamideGTPL9108orb1304109SCHEMBL2048345CHEMBL3644252SCHEMBL29370287SCHEMBL30772280JUPOTOIJLKDAPF-UHFFFAOYSA-N
데이터베이스 식별자
- PubChem CID
- 67259771
- ChEMBL
CHEMBL3644252
물성
구조 계산 물성
- XLogP
- 3.9
- 극성 표면적
- 92.8 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 42
- 형식 전하
- 0
- 복잡도
- 913
관련 반응
1건
화합물 노트
불러오는 중…