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기본 정보
- CAS
545395-94-6- 표준 SMILES
CC(C)(C)c1ccc(/C=C/C(=O)Nc2ccc3c(c2)OCCO3)cc1- InChIKey
GZTFUVZVLYUPRG-IZZDOVSWSA-N- 분자식
- C21H23NO3
- 평균 분자량
- 337.41 g/mol
이름 및 식별자
- 우선 이름
- AMG 9810
- 영어명
- AMG 9810
- 분자식
- C21H23NO3
- 분자량
- 337.41
이름 및 동의어
9810CS-2548AMG 9810AMG-9810 ，S6934AMG 9810AMG-9810AMG9810, 10 mM in DMSOAMG 9810 >=98% (HPLC), powder(2E)-N-(2，3-Dihydro-1，4-benzodiAMG 9810, TRPV1 receptor antagonist3-[4-(TERT-BUTYL)PHENYL]-N-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)ACRYLAMIDE
데이터베이스 식별자
- CAS
545395-94-6- PubChem CID
- 680502
- ChEMBL
CHEMBL195789- ChEBI
CHEBI:92757- UNII
- 182HIJ2D7F
- EC Number
- 637-276-2
- Nikkaji
- J2.933.467F
물성
물리화학적 성질
- 끓는 점
- 512.5 · 512.5±50.0 °C(Predicted)
- 밀도
- 1.175 · 1.175±0.06 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 5 mg/mL · 에 용해됨 DMSO: >5mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 12.22 · 12.22±0.20(Predicted)
- 색상
- 흰색에서 베이지색
- InChI
- 1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
- InChIKey
- GZTFUVZVLYUPRG-IZZDOVSWSA-N
- SMILES
- CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- risk_code
- 22
- hazard_code
- Xn
- Hazard Classifications
- Acute Tox. 4 OralAquatic Chronic 4
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.
용도AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat, respectively). Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands: anandamide, N-arachidonyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine. In a rat model of inflammatory pain induced by intraplantar injection of complete Freund’s adjuvant, 30-100 mg/kg AMG 9810 reverses thermal and mechanical hyperalgesia.[Cayman Chemical]
공급사70 곳
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 19370895928 · [email protected]
上海优宁维生物科技股份有限公司
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