Dictamnine

135.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

133.64 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Phytophotodermatitis can be prevented by staying indoors after handling dictamnine. Windows will filter out ultraviolet light and prevent symptoms from arising. Many different topical and oral medications can be used to treat the inflammatory reaction of phytophotodermatitis. A dermatologist may also prescribe a bleaching cream to help treat the hyperpigmentation and return the skin pigmentation back to normal. If they do not receive treatment, the affected sites may develop permanent hyperpigmentation or hypo pigmentation. Sunblock can greatly mitigate symptoms, at least when caused by rue (Ruta Graveolens). (Wikipedia)

Dictamnine may play a major role in the elicitation of phytophotodermatitis (A15434). Phytophotodermatitis, also known as "Lime Disease" (not to be confused with Lyme Disease), "Berloque dermatitis", or "Margarita photodermatitis" is a chemical reaction which makes skin hypersensitive to ultraviolet light. It is caused by contact with photosensitizing compounds. (Wikipedia)

Dictamnine is the main alkaloid in the roots of Dictamnus albus, and occurs in other plants of the Rutaceae family. Dictamnine has been reported to have antimicrobial activity against bacteria and fungi. Dictamnine has anti-platelet aggregation and vascular-relaxing activities, insecticidal activities, phototoxicity to bacteria and yeast and antibacterial activity against Mycobacterium smegmatis and Bacillus subtilis. Dictamnine has also been widely used to treat certain skin diseases. (A15435)