기본 정보
- CAS
17440-83-4- 표준 SMILES
Cl.NC(N)=NC(=O)c1nc(Cl)c(N)nc1N.O.O- InChIKey
LTKVFMLMEYCWMK-UHFFFAOYSA-N- 분자식
- C6H13Cl2N7O3
- 평균 분자량
- 302.12 g/mol
- 단동위원소 질량
- 301.0456927
개요
Amiloride hydrochloride appears as crystalline solid or very light yellow powder. (NTP, 1992)
이름 및 식별자
- 우선 이름
- Amiloride Hydrochloride
- IUPAC
- 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
- 영어명
- Amiloride hydrochloride dihydrate
- 분자식
- C6H8ClN7O.HCl.2H2O
- 분자량
- 302.12
이름 및 동의어
Amiloride hydrochloride dihydrate17440-83-4ModamideAmiloride HCLAmilorid hydrochlorid-2-wasserAMIPRAMIDINEAmilamontAmorideBerkamilAmilospare 5FZJ37245UCAmiloride hydrochloride dehydrate
이름 더 보기
AMiloridaAMILORIDE HCL DIHYDRATEAmiloride hydrochloridAMiloride hydrocholrideAMILORIDEHYDROCHLORIDE,USPMK-870 hydrochloride dihydrateAMILORIDE HYDROCHLORIDE (500 MG)Miloride hydrochloride dihydrateAmiloride HCl dihydrate (MK 870)
NSC-755847CHEBI:2640DTXSID80169826Pyrazinecarboxamide, N-amidino-3,5-diamino-6-chloro-, monohydrochlorideDTXCID504452CHEBI:84743Hydrochloride, AmilorideRefChem:557170
데이터베이스 식별자
- CAS
17440-83-4、2016-88-8- PubChem CID
- 68540
- DTXSID
DTXSID80169826
물성
구조 계산 물성
- 극성 표면적
- 161 Ų
- 수소 결합 공여자 수
- 7
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 18
- 형식 전하
- 0
- 복잡도
- 279
실험 및 물리화학적 성질
Solubilityless than 1 mg/mL at 67.1 °F (NTP, 1992)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Melting Point560.3 °F (NTP, 1992)
Physical DescriptionAmiloride hydrochloride appears as crystalline solid or very light yellow powder. (NTP, 1992)
물리화학적 성질
- 녹는점
- 240 ℃ · >240℃
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 물과 무수 에탄올에 약간 용해됩니다.
- 산도 계수 (pKa)
- 8.7 · 8.7(at 25℃)
- 물리적 상태
- Solid
- 색상
- Off-white to yellow
- 수용성
- 50 mg/ml의 · 50mg/ml의 물에 용해됨
- 주요 응용
- 제약
- InChI
- InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
- InChIKey
- LTKVFMLMEYCWMK-UHFFFAOYSA-N
- SMILES
- C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H]
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (90.2%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P264+P265, P270, P273, P280, P301+P316, P305+P351+P338, P321, P330, P337+P317, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Amiloride hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Amiloride hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
DOT LabelPoison
Fire HazardsFlash point data for this material are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards
SYMPTOMS: Symptoms of exposure to this compound include headache, weakness, fatigue, back, chest, neck, shoulder or extremity pain; nausea, anorexia, vomiting, abdominal pain, hyperkalemia, paresthesias, shock, dizziness, coughing, shortness of breath, depression, nervousness, flaccid paralysis of the extremities, bradycardia, flatulence, skin rash, gas pain, constipation and dyspnea. (NTP, 1992)
Reactive GroupAmides and Imides
Reactivity Profile
A halide- and amine-substituted aromatic compound, with amide and acidic salt components. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
화학 및 산업
약리 정보
FDA Pharmacological Classification
AMILORIDE HYDROCHLORIDE
Decreased Renal K+ Excretion [PE]; Potassium-sparing Diuretic [EPC]; Increased Diuresis [PE]
MeSH Pharmacological Classification
Agents that promote the excretion of urine through their effects on kidney function.
A subclass of sodium channel blockers that are specific for ACID-SENSING SODIUM CHANNELS.
A subclass of sodium channel blockers that are specific for EPITHELIAL SODIUM CHANNELS.
응용 분야
용도Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 M. Amiloride HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
공급사98 곳
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]
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