Tetramisole Hydrochloride
LEVAMISOLE HCL · TETRAMISOLE HCL · LEVAMISOL HYDROCHLORIDE · citarinl · ERGAMISOL · Levamisole HCI · decaris · Levadin
식별자 및 물리적 특성
| CAS No. | 16595-80-5 |
|---|---|
| 분자식 | C11H13ClN2S |
| 평균 분자량 | 240.75 g/mol |
| 단동위원소 질량 | 240.0487971 g/mol |
| SMILES | Cl.c1ccc(C2CN3CCSC3=N2)cc1 |
| InChIKey | LAZPBGZRMVRFKY-UHFFFAOYSA-N |
| PubChem CID | 68628 |
| ChEMBL | CHEMBL554891 |
| ChEBI | CHEBI:9496 |
| EC No. | 225-799-5 |
| DTXSID | DTXSID101017245 |
화학 및 물리적 성질
| 극성 표면적 | 40.9 |
|---|---|
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 1 |
| 무거운 원자 수 | 15 |
| 형식 전하 | 0 |
| 복잡도 | 246 |
| 용해도 | >36.1 [ug/mL] (The mean of the results at pH 7.4)물에 잘 녹고, 에탄올(96%)에 녹고, 염화메틸렌에는 약간 녹습니다. |
| 녹는점 | 266-267 °C(lit.) |
| 굴절률 | -126 ° (C=1, H2O) |
| 인화점 | 9℃ |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 결정성 분말 |
| 색상 | 흰색에서 거의 흰색 |
| 생물학적 소스 | synthetic (organic) |
| 용해도 | 210g/L(20℃) |
| Merck | 14,5459 |
| BRN | 4358988 |
| BCS Class | 3/1 |
| 안정성 | 흡습성 |
| 주요 응용 | 법의학 및 독성학의약품(소분자) |
| InChI | InChI=1/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H21H/t10-/s3 |
| InChIKey | LAZPBGZRMVRFKY-HNCPQSOCSA-N |
| SMILES | [C@H]1(N=C2SCCN2C1)C1=CC=CC=C1.Cl |&1:0,r| |
| LogP(분배 계수) | 1.845 (est) |
| EPA | Levamisole hydrochloride (16595-80-5) |
화학적 성질
White to light yellow crystalline powder, odorless, bitter taste. Melting point 227-229℃. Soluble in water, methanol, ethanol and glycerol, slightly soluble in chloroform and aether; insoluble in acetone. Stable under acidic conditions, but easy to decompose and fail under alkaline conditions.
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 0.9% (1 of 116) of reports.WarningH302 (99.1%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 116 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Tetramisole hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 기타 안전 정보 | IMAP assessments - Imidazo[2,1-b]thiazole, 2,3,5,6-tetrahydro-6-phenyl-, monohydrochloride, (.+-.)-: Human health tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (99.1%) |
| 수질 위해 등급(WGK) | 3 |
| RTECS 번호 | NJ5960000 |
| 운송 번호(UN) | UN 2811 6.1/PG 3 |
| 관세 코드 | 29349990 |
| 위험 문구(R) | 25-20/21/22-39/23/24/25-23/24/25-11 |
| 위험 표시 | T,Xn,F |
| 안전 문구(S) | 36/37/39-45-28A-36-36/37-16 |
| 포장분류 | III |
| 위험 등급 | 6.1(b)Acute Tox. 3 Oral |
| 기존화학 물질 | KE-33497 |
| F 고인화성물질 | 10 |
| 저장 분류 | 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects |
용도
용도
Levamisole hydrochloride is an anthelmintic. The activity of levamisole is about twice as high as that of abscisicidal, and the toxicity and side effects are lower. Levamisole can cause muscle paralysis of roundworms and then excrete them in the feces. It is mainly used as an anti-worm and anti-hookworm.
용도
Biological response modifier with anthelmintic activity. Anthelmintic (nematodes); immunomodulator.
제조 및 합성 방법
제조 방법
Levamisole hydrochloride was prepared from racemic tetraimidazole by splitting, alkali analysis and acidification into salt.Dibenzoyl-D-tartaric acid is boiled in water for 40min, hydrolyzed and neutralized with sodium hydroxide solution to pH 7.5, and then added to racemic tetraimidazole. The levamisole is precipitated by generating salt with bisbenzoyl-tartaric acid. After separation, add sodium hydroxide solution to PH=9 and decompose levamisole. Then dissolved in dilute hydrochloric acid solution, after decolorization by activated carbon, the filtrate was concentrated nearly dry, and crystallized by adding acetone and cooling to 0℃. Filtered and dried to obtain levamisole hydrochloride.