기본 정보
- CAS
54187-04-1- 표준 SMILES
C1COC(NC(C2CC2)C2CC2)=N1- InChIKey
CQXADFVORZEARL-UHFFFAOYSA-N- 분자식
- C10H16N2O
- 평균 분자량
- 180.25 g/mol
- 단동위원소 질량
- 180.12626313
개요
Rilmenidine is an isourea.
이름 및 식별자
- 우선 이름
- Rilmenidine
- IUPAC
- N-(dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
- 영어명
- Rilmenidine
- 분자식
- C10H16N2O
- 분자량
- 180.25
이름 및 동의어
Rilmenidine54187-04-1OxaminozolineHyperiumRilmenidinumrilmenidina2-Oxazolamine, N-(dicyclopropylmethyl)-4,5-dihydro-DTXSID3045194P67IM25ID8S 3341S-3341DTXCID1025194
이름 더 보기
s3341TenaxumS-3341-3TENAXUMRilmenidine USP/EP/BPRilmenidinehemifuramateRilMenidine heMifuMarate sa
RefChem:179457C02AC06s33413S 3341 3259-021-02-(N-(Dicyclopropylmethyl)amino)oxazolineN-(Dicyclopropylmethyl)-4,5-dihydrooxazol-2-amineN-(Dicyclopropylmethyl)-4,5-dihydro-1,3-oxazol-2-amine
데이터베이스 식별자
- CAS
54187-04-1- PubChem CID
- 68712
- DTXSID
DTXSID3045194- ChEMBL
CHEMBL289480- ChEBI
CHEBI:8862- UNII
- P67IM25ID8
- EC Number
- 259-021-0
- Nikkaji
- J23.709D
물성
구조 계산 물성
- XLogP
- 1.2
- 극성 표면적
- 33.6 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 13
- 형식 전하
- 0
- 복잡도
- 219
실험 및 물리화학적 성질
Drugs
Pharmaceuticals -> Listed in ZINC15
Pharmaceutical
LogP1.63
물리화학적 성질
- 녹는점
- 106 · 106-107°
- 끓는 점
- 355.5 · 355.5±9.0 °C(Predicted)
- 밀도
- 1.45 · 1.45±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 2 O: · H2O: 7.3 mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 7.88 · 7.88±0.50(Predicted)
- 색상
- 하얀색
화학적 성질
water soluble
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Drug Induced Liver Injury
Drug-Induced Liver Injury Severity and Toxicity (DILIst)
Rilmenidine
DILI Positive
DOI:10.1016/j.drudis.2019.09.022
안전 데이터
- wgk
- 3
- rtecs
- RP7207400
- safety_code
- 22-24/25
화학 및 산업
약리 정보
ATC Code
C02AC06
C - Cardiovascular system
QC - Cardiovascular system
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
응용 분야
개요Rilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist profile, reportedly useful in the management of mild to moderate hypertension. Its fmt-line indication is possible because of the clear dissociation of its antihypertensive activity from other neurophannacological effects.
용도I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine
상·하류 제품 정보
상류 원료
관련 반응
2건
화합물 노트
불러오는 중…