기본 정보
- CAS
60762-57-4- 표준 SMILES
Cc1ccc2c(c1)c1c3n2CCNC3CCC1- InChIKey
IWVRVEIKCBFZNF-UHFFFAOYSA-N- 분자식
- C15H18N2
- 평균 분자량
- 226.32 g/mol
- 단동위원소 질량
- 226.14699858
개요
LSM-1636 is a member of carbazoles.
이름 및 식별자
- 우선 이름
- Pirlindole
- IUPAC
- 12-methyl-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene
- 영어명
- 2,3,3A,4,5,6-HEXAHYDRO-8-METHYL-1H-PYRAZINO[3,2,1-J,K]CARBAZOLE MESYLATE
- 분자식
- C15H18N2
- 분자량
- 226.32
이름 및 동의어
Pirlindole60762-57-4pirlindolPyrazidol8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino[3,2,1-jk]carbazolePirlindolumV39YPH45FZDTXSID8048230pyrlindole1H-Pyrazino(3,2,1-jk)carbazole, 2,3,3a,4,5,6-hexahydro-8-methyl-, monohydrochloride8-Methyl-2,3,3a,4,5,6-hexahydro-1H-pyrazino(3,2,1-jk)carbazoleRefChem:174549
이름 더 보기
Unii-V39yph45fzPIRLINDOLE MESYLATEOmbitasvir Impurity 6Pirlindolum [inn-latin]Pirlindol [inn-spanish, french]
DTXCID90282051,10-trimethylene-8-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole12-methyl-1,4-diazatetracyclo(7.6.1.0?,1?.01?,1?)hexadeca-9(16),10,12,14-tetraenePirlindole free basePirlindole [INN]Pirazidol12-methyl-1,4-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-9(16),10(15),11,13-tetraene2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino(3,2,1-jk)carbazole
데이터베이스 식별자
- CAS
60762-57-4- PubChem CID
- 68802
- DTXSID
DTXSID8048230
물성
구조 계산 물성
- XLogP
- 2.3
- 극성 표면적
- 17 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 17
- 형식 전하
- 0
- 복잡도
- 303
물리화학적 성질
- 저장 조건
- Store at RT
- 용해도
- 1 mg/ml; · DMF: 1 mg/ml; DMSO: 5 mg/ml
- 물리적 상태
- 결정성 고체
- 색상
- Off-white to light yellow
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P264+P265, P273, P280, P305+P351+P338, P337+P317, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesEye Irrit. 2 (100%)
안전 데이터
- 위험 등급
- IRRITANT
화학 및 산업
약리 정보
Protein Binding97% binding to plasma proteins
PharmacodynamicsPirlindole regulates that metabolism of norepinephrine and catecholamines, leading to relief of depressive symptoms. The prevention of breakdown of these neuromodulators is thought to elevate mood.
Mechanism of Action
This drug is a selective and reversible inhibitor of monoamine oxidase A (also known as MAO-A). Its main mechanism of action is selective and reversible inhibition of monoamine oxidase A. Its secondary mechanism of action is the inhibition effect of noradrenaline and 5-hydroxytryptamine reuptake.
Biological Half-Life0.7±0.3 in one study of healthy volunteers
Metabolism/Metabolites
The drug is metabolized significantly through the hepatic system. From studies in dogs and rats, pirlindole has a bioavailability of between 20 and 30% due to the hepatic first-pass effect on this medication. The rat eliminates mainly unconjugated drug while the dog eliminates mostly conjugated drug.
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
Absorption, Distribution and Excretion
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…