N,O-비스(트리메틸시릴)아세트아마이드
N,O-bis(trimethylsilyl)acetamide
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기본 정보
- CAS
10416-59-8- 표준 SMILES
C/C(=N\[Si](C)(C)C)O[Si](C)(C)C- InChIKey
SIOVKLKJSOKLIF-CMDGGOBGSA-N- 분자식
- C8H21NOSi2
- 평균 분자량
- 203.43 g/mol
이름 및 식별자
- 우선 이름
- N,O-bis(trimethylsilyl)acetamide
- IUPAC
- trimethylsilyl (1E)-N-trimethylsilylethanimidate
- 현지명
- N,O-비스(트리메틸시릴)아세트아마이드
- 영어명
- N,O-Bis(trimethylsilyl)acetamide
- 분자식
- C8H21NOSi2
- 분자량
- 203.43
이름 및 동의어
Trimethylsilyl N-trimethylsilylacetamidateR14N49I64ODTXCID1030074Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl esterDTXSID5051525RefChem:161345233-892-710416-59-8Bis(trimethylsilyl)acetamideN,O-bis(trimethylsilyl)acetamideMFCD00008270ACETIMIDIC ACID, N-(TRIMETHYLSILYL)-, TRIMETHYLSILYL ESTER
이름 더 보기
N,O-비스(트리메틸시릴)아세트아마이드N,O-비스(트리메틸시릴)아세트아미드N,O-비스(트리메틸시릴)아세트아마이드(N,O-BIS(TRIMETHYLSILYL)ACETAMIDE)TMS-BAtrimethylsilyl N-trimethylsilylethanimidatetrimethylsilyl (E)-N-(trimethylsilyl)acetimidateCB2500bis(trimethylsllyl)acetamideN.O-Bis(trimethylsilyl)acetamide (BSA)
Trimethylsilyl (1E)-N-(trimethylsilyl)ethanimidateTRIMETHYLSILYL N-(TRIMETHYLSILYL)ACETIMIDATEN-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester132255-83-5Dynasylan BSABSAtrimethylsilyl (1E)-N-trimethylsilylethanimidateEINECS 233-892-7
데이터베이스 식별자
- CAS
10416-59-8- PubChem CID
- 6913588
- UNII
- R14N49I64O
- EC Number
- 233-892-7
- Nikkaji
- J10.472H
물성
구조 계산 물성보충 중
- 극성 표면적
- 21.6 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 12
- 형식 전하
- 0
- 복잡도
- 176
실험 및 물리화학적 성질
Chemical ClassesMetals -> Metalloid Compounds (Silicon)
Physical DescriptionColorless or pale yellow liquid; [Alfa Aesar MSDS]
물리화학적 성질
- 녹는점
- 24 °C · 24 °C
- 끓는 점
- 71 · 71-73 °C35 mm Hg(lit.)
- 밀도
- 0.832 g/mL · 0.832 g/mL at 20 °C(lit.)
- 증기압
- 10 hPa · 10 hPa (50 °C)
- 굴절률
- 20 · n20/D 1.417(lit.)
- 인화점
- 53 °F · 53 °F
- 저장 조건
- 30 °C · Store below +30°C.
- 용해도
- 많은 비극성 및 극성 비양성자성 용매와 섞일 수 있습니다.
- 물리적 상태
- 결정질 분말, 결정 및/또는 덩어리
- 산도 계수 (pKa)
- 5.82 · 5.82±0.50(Predicted)
- Specific Gravity
- 0.832 · 0.832
- 색상
- 연한 노란색 또는 베이지색에서 갈색까지
- BRN
- 1306669 · 1306669
- InChI
- 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H226 (97.8%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P330, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 91 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester
Status: Active Update: 04-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/34060
Trimethylsilyl N-trimethylsilylacetamidate: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Causes decreased immune response in intraperitoneal lethal-dose studies of mice (LD50 = 750 mg/kg); [RTECS] Reacts violently with water; Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Alfa Aesar MSDS]
Hazard Classes and CategoriesFlam. Liq. 3 (97.8%)
독성 정보
Adverse EffectsDermatotoxin - Skin burns.
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- AK3000000
화학 및 산업
용도 및 제조
General Manufacturing InformationEthanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester: ACTIVE
응용 분야
용도N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional groups.BSA was used to trimethylsilylate the hydroxyl group of 12 selectively to form in almost quantitative yield (eq 32).The presence of catalytic amounts (～0.02 equiv) of tetrabutylammonium fluoride (TBAF) significantly promoted the silylation of alcohols under mild conditions with high chemoselectivity, i.e., TBAF plays a role as a smooth silyl transfer catalyst from nitrogen to the hydroxyl group.
일반 설명N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.
제조 방법
N,O-Bis(trimethylsilyl)acetamide is made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.
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