기본 정보
- CAS
197855-65-5- 표준 SMILES
CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)CF- InChIKey
ASXVEBPEZMSPHB-PKHIMPSTSA-N- 분자식
- C21H23FN2O4
- 평균 분자량
- 386.4 g/mol
- 단동위원소 질량
- 386.16418538
이름 및 식별자
- 우선 이름
- Z-Phe-DL-Ala-fluoromethylketone
- IUPAC
- benzyl N-[(2S)-1-[(4-fluoro-3-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamate
- 영어명
- Z-Phe-DL-Ala-fluoromethylketone
- 분자식
- C21H23FN2O4
- 분자량
- 386.42
이름 및 동의어
197855-65-5Z-FA-FMKZ-Phe-DL-Ala-fluoromethylketonebenzyl N-[(2S)-1-[(4-fluoro-3-oxobutan-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamateZ-Fa-fmk, (DL-a)-Benzyloxycarbonyl-Phe-DL-Ala-fluoromethylketoneMDL-201053, (DL-alanine)-Benzyl ((2S)-1-((4-fluoro-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate34O3P3306ZCarbamic acid, N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl esterC21H23FN2O4benzyl N-[(1S)-1-[(4-fluoro-3-oxobutan-2-yl)carbamoyl]-2-phenylethyl]carbamate
이름 더 보기
CS-1504Z-Phe-DL-Ala-FMKZ-FA-FMK, 10 mM in DMSOInhibitor of cysteine proteasesNalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)PhenylalaninamideNalpha-[(Benzyloxy)Carbonyl]-N-(4-Fluoro-3-Oxo-2-Butanyl)Phenylalaninamide z-fa-fmkCarbamic acid,N-[(1S)-2-[(3-fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-,phenylmethyl esterSARS coronavirus,SARS-CoV,RRMs,DNA fragmentation,DEVDase,Caspase,Cathepsin,Inhibitor,externalization of phosphatidylserine,Apoptosis,inhibit,Z FA FMK,reovirus replication,ZFAFMK
Carbamic acid, (2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester, (1(S))-Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl esterMdl-201053N-[(1S)-2-[(3-Fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid Phenylmethyl Ester; [1(S)]-[2-[(3-Fluoro-1-methyl-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid Phenylmethyl EsterMFCD02684535CHEMBL54797orb1300512SCHEMBL7301289
데이터베이스 식별자
- CAS
197855-65-5- PubChem CID
- 6915837
- DTXSID
DTXSID701336087- ChEMBL
CHEMBL54797- UNII
- 34O3P3306Z
- Nikkaji
- J510.992B
물성
구조 계산 물성
- XLogP
- 3.3
- 극성 표면적
- 84.5 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 10
- 무거운 원자 수
- 28
- 형식 전하
- 0
- 복잡도
- 517
물리화학적 성질
- 끓는 점
- 630.5 · 630.5±55.0 °C(Predicted)
- 밀도
- 1 · 1+-.0.06 g/cm3(Predicted)
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 5 mg/ml; · DMF: 5 mg/ml; DMSO: 5 mg/ml
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 11.07 · 11.07±0.46(Predicted)
- 색상
- White to off-white
- InChIKey
- ASXVEBPEZMSPHB-PKHIMPSTSA-N
- SMILES
- C(OCC1=CC=CC=C1)(=O)N[C@@H](CC1=CC=CC=C1)C(NC(C)C(=O)CF)=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- HS 번호
- 29145090
화학 및 산업
응용 분야
개요Z-FA-FMK is an irreversible inhibitor of cysteine proteases, including cathepsins B, L, and S, cruzain, and papain. It also inhibits effector caspases-2, -3, -6, and -7 (IC50 = 6-32 μM) without affecting the initiator caspases-8 and -10. Z-FA-FMK also modulates infection by certain bacteria, parasites, and viruses. It can be used both in cells and in vivo.
용도Z-FA-FMK is an irreversible cysteine protease inhibitor. It also inhibits papain and cruzain.
공급사77 곳
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
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杭州品高化工有限公司0571-87658025 · [email protected]
上海海皋科技有限公司021-57646680 18306277365 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
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欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
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