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역사Adriamycin was first discovered in 1967 by Arcamone, Cassinelli, Di Marco, and Gaetani at the FI Research Laboratory. It was found in cultures of a mutant Streptomyces peucetius (Streptomyces peucetius caesius) (Arcamone, 1969). The compound's chemical structure is very similar to daunomycin, the only difference being that a hydrogen atom on the acetyl group is replaced by a hydroxyl group. The new compound is named after the view of the Adriatic Sea from Castel del Monte, where the strain that produced it was isolated. Subsequently, researchers conducted extensive preclinical, pharmacological, toxicological, and formulation studies. However, it wasn't until 1969, when Monfardini published authoritative results in a journal confirming the drug's broad activity spectrum, that it gained widespread attention from the scientific community.

용도Doxorubicin (adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumour agent for the treatment of a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.